Hook3 hook microtubule-tethering protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hook3provided by RGD
Official Full Name: hook microtubule-tethering protein 3provided by RGD
Primary source: RGD:1560960
See related: Ensembl:ENSRNOG00000014275 AllianceGenome:RGD:1560960
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including cytoskeletal protein binding activity; dynein intermediate chain binding activity; and dynein light chain binding activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to act upstream of or within several processes, including interkinetic nuclear migration; microtubule anchoring at centrosome; and neuronal stem cell population maintenance. Predicted to be located in centriolar satellite; cis-Golgi network; and pericentriolar material. Predicted to be part of FHF complex. Orthologous to human HOOK3 (hook microtubule tethering protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 322.0), Lung (RPKM 272.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.4

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (72656929..72751696)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (65954293..66058812)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (70710347..70818789)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hook3 interacts with a cytoplasmic domain of scavenger receptor A
Title: The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynactin binding	ISO Inferred from Sequence Orthology more info
enables dynein intermediate chain binding	ISO Inferred from Sequence Orthology more info
enables dynein light chain binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi localization	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton-dependent intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interkinetic nuclear migration	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microtubule anchoring at centrosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of FHF complex	ISO Inferred from Sequence Orthology more info
part_of HOPS complex	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in pericentriolar material	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Hook homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136098.1 → NP_001129570.1 protein Hook homolog 3

See identical proteins and their annotated locations for NP_001129570.1

Status: PROVISIONAL

Source sequence(s)

CH473970

UniProtKB/TrEMBL

A0A8I5ZWS4, A0A8I6AQA0, A6IVZ4

Related

ENSRNOP00000091293.1, ENSRNOT00000097055.1

Conserved Domains (2) summary

pfam05622
Location:184 → 709

HOOK; HOOK protein

cl41774
Location:8 → 160

HkD_SF; Hook domain-containing proteins superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

72656929..72751696

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094555.2 → XP_038950483.1 protein Hook homolog 3 isoform X1

Conserved Domains (2) summary

pfam05622
Location:184 → 546

HOOK; HOOK protein

cd22226
Location:8 → 160

HkD_Hook3; Hook domain found in protein Hook 3 (Hook3) and similar proteins