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Atp11a ATPase phospholipid transporting 11A [ Rattus norvegicus (Norway rat) ]

Gene ID: 306600, updated on 13-Apr-2024

Summary

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Official Symbol
Atp11aprovided by RGD
Official Full Name
ATPase phospholipid transporting 11Aprovided by RGD
Primary source
RGD:1308688
See related
Ensembl:ENSRNOG00000017154 AllianceGenome:RGD:1308688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ua20
Summary
Predicted to enable phosphatidylethanolamine flippase activity and phosphatidylserine flippase activity. Predicted to be involved in phospholipid translocation and positive regulation of myotube differentiation. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be integral component of plasma membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in several cellular components, including endoplasmic reticulum; recycling endosome; and trans-Golgi network. Orthologous to human ATP11A (ATPase phospholipid transporting 11A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 741.0), Lung (RPKM 304.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atp11a in Genome Data Viewer
Location:
16q12.5
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (83359884..83469807, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76657752..76767640, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81990340..82100222, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482421 Neighboring gene coagulation factor VII Neighboring gene MCF.2 cell line derived transforming sequence-like Neighboring gene uncharacterized LOC102548949 Neighboring gene uncharacterized LOC134482533 Neighboring gene tubulin gamma complex component 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. Takatsu H, et al. J Biol Chem, 2011 Nov 4. PMID 21914794, Free PMC Article
  2. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
  3. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylethanolamine flippase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine flippase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in aminophospholipid translocation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane lipid distribution ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phospholipid-transporting ATPase IH
Names
ATPase, class VI, type 11A
UA20 protein-like
probable phospholipid-transporting ATPase IH
NP_001100794.2
NP_001401946.1
NP_001401947.1
XP_017455639.1
XP_017455641.1
XP_017455642.1
XP_063131532.1
XP_063131533.1
XP_063131534.1
XP_063131535.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107324.2 → NP_001100794.2  phospholipid-transporting ATPase IH isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6IWL3, D4A7K5
    Related
    ENSRNOP00000023163.5, ENSRNOT00000023163.7
    Conserved Domains (7) summary
    TIGR01652
    Location:45 → 1106
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:102 → 187
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:477 → 587
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:42 → 95
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:854 → 1106
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl00297
    Location:641 → 697
    R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
    cl21460
    Location:809 → 852
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. NM_001415017.1 → NP_001401946.1  phospholipid-transporting ATPase IH isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    Related
    ENSRNOP00000081780.1, ENSRNOT00000117454.1

  3. NM_001415018.1 → NP_001401947.1  phospholipid-transporting ATPase IH isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A0G2K8V1
    Related
    ENSRNOP00000074747.2, ENSRNOT00000089447.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    83359884..83469807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275464.1 → XP_063131534.1  phospholipid-transporting ATPase IH isoform X6

  2. XM_017600150.2 → XP_017455639.1  phospholipid-transporting ATPase IH isoform X1

    UniProtKB/TrEMBL
    A6IWL3

  3. XM_063275465.1 → XP_063131535.1  phospholipid-transporting ATPase IH isoform X6

  4. XM_017600152.3 → XP_017455641.1  phospholipid-transporting ATPase IH isoform X2

    UniProtKB/TrEMBL
    A6IWL3

  5. XM_017600153.3 → XP_017455642.1  phospholipid-transporting ATPase IH isoform X4

    UniProtKB/TrEMBL
    A6IWL3

  6. XM_063275463.1 → XP_063131533.1  phospholipid-transporting ATPase IH isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZTL7, A6IWL2

  7. XM_063275462.1 → XP_063131532.1  phospholipid-transporting ATPase IH isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144742.1: Suppressed sequence

    Description
    NM_144742.1: This RefSeq was removed because it is primarily UTR sequence.
Nucleotide Protein Strain
Heading Accession and Version

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