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Myom2 myomesin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306616, updated on 3-Apr-2024

Summary

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Official Symbol
Myom2provided by RGD
Official Full Name
myomesin 2provided by RGD
Primary source
RGD:631437
See related
Ensembl:ENSRNOG00000011754 AllianceGenome:RGD:631437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity and kinase binding activity. Involved in extraocular skeletal muscle development. Located in M band. Orthologous to human MYOM2 (myomesin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 5309.4) and Muscle (RPKM 4093.1) See more
Orthologs
human mouse all
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Genomic context

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See Myom2 in Genome Data Viewer
Location:
16q12.5
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (81222467..81295025, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (74520148..74592658, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (79587136..79672871, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097555 Neighboring gene ribosomal oxygenase 2, pseudogene 2 Neighboring gene uncharacterized LOC102551089 Neighboring gene uncharacterized LOC102551149 Neighboring gene kelch repeat and BTB domain containing 11 Neighboring gene uncharacterized LOC134482526 Neighboring gene Rho guanine nucleotide exchange factor 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. M-protein is down-regulated in cardiac hypertrophy driven by thyroid hormone in rats. Rozanski A, et al. Mol Endocrinol, 2013 Dec. PMID 24176915, Free PMC Article
  2. CaMKII regulates the proteins TPM1 and MYOM2 and promotes diacetylmorphine-induced abnormal cardiac rhythms. Ji M, et al. Sci Rep, 2023 Apr 10. PMID 37037889, Free PMC Article
  3. Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle. Porter JD, et al. J Exp Biol, 2003 Sep. PMID 12878677
  4. The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins. Vinkemeier U, et al. J Cell Sci, 1993 Sep. PMID 7505783
  5. Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein. Hornemann T, et al. J Mol Biol, 2003 Sep 26. PMID 12972258

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CaMKII regulates the proteins TPM1 and MYOM2 and promotes diacetylmorphine-induced abnormal cardiac rhythms.
    Title: CaMKII regulates the proteins TPM1 and MYOM2 and promotes diacetylmorphine-induced abnormal cardiac rhythms.
  2. the M-protein expression is strongly and rapidly repressed by triiodothyronine in cardiomyocytes.
    Title: M-protein is down-regulated in cardiac hypertrophy driven by thyroid hormone in rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in extraocular skeletal muscle development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sarcomere organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in M band ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myomesin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001169141.1 → NP_001162612.1  myomesin-2

    See identical proteins and their annotated locations for NP_001162612.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6IWD0, G3V7K1
    Conserved Domains (6) summary
    cd05891
    Location:1345 → 1436
    IgI_M-protein_C; C-terminal immunoglobulin (Ig)-like domain of M-protein; member of the I-set of Ig superfamily (IgSF) domains
    PHA02826
    Location:1238 → 1433
    PHA02826; IL-1 receptor-like protein; Provisional
    cd00063
    Location:383 → 475
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:1146 → 1200
    Ig; Immunoglobulin domain
    cd20951
    Location:154 → 247
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:290 → 372
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    81222467..81295025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094595.2 → XP_038950523.2  myomesin-2 isoform X2

  2. XM_063275476.1 → XP_063131546.1  myomesin-2 isoform X1

    UniProtKB/TrEMBL
    A6IWD0

  3. XM_063275477.1 → XP_063131547.1  myomesin-2 isoform X1

    UniProtKB/TrEMBL
    A6IWD0

  4. XM_006253389.5 → XP_006253451.1  myomesin-2 isoform X1

    See identical proteins and their annotated locations for XP_006253451.1

    UniProtKB/TrEMBL
    A6IWD0, G3V7K1
    Related
    ENSRNOP00000015908.6
    Conserved Domains (6) summary
    cd05891
    Location:1345 → 1436
    IgI_M-protein_C; C-terminal immunoglobulin (Ig)-like domain of M-protein; member of the I-set of Ig superfamily (IgSF) domains
    PHA02826
    Location:1238 → 1433
    PHA02826; IL-1 receptor-like protein; Provisional
    cd00063
    Location:383 → 475
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:1146 → 1200
    Ig; Immunoglobulin domain
    cd20951
    Location:154 → 247
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:290 → 372
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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