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F12 coagulation factor XII [ Rattus norvegicus (Norway rat) ]

Gene ID: 306761, updated on 4-Jan-2025

Summary

Official Symbol
F12provided by RGD
Official Full Name
coagulation factor XIIprovided by RGD
Primary source
RGD:1359175
See related
EnsemblRapid:ENSRNOG00000015139 AllianceGenome:RGD:1359175
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HAF
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including positive regulation of plasminogen activation; protein maturation; and regulation of blood coagulation. Located in extracellular space. Used to study hyperhomocysteinemia. Human ortholog(s) of this gene implicated in angioedema (multiple); cerebrovascular disease (multiple); factor XII deficiency; and myocardial infarction. Orthologous to human F12 (coagulation factor XII). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 1746.7) See more
Orthologs
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Genomic context

See F12 in Genome Data Viewer
Location:
17p14
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9212819..9220664)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9207683..9215530)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9736577..9744420)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene proline rich 7 (synaptic) Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene solute carrier family 34 member 1 Neighboring gene profilin 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding  
enables peptidase activity  
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity  
Process Evidence Code Pubs
involved_in Factor XII activation  
involved_in Factor XII activation  
involved_in blood coagulation  
involved_in blood coagulation  
acts_upstream_of_or_within blood coagulation  
involved_in fibrinolysis  
involved_in plasma kallikrein-kinin cascade  
involved_in positive regulation of blood coagulation  
involved_in positive regulation of blood coagulation  
involved_in positive regulation of fibrinolysis  
involved_in positive regulation of fibrinolysis  
involved_in positive regulation of plasminogen activation  
involved_in positive regulation of plasminogen activation  
involved_in protein autoprocessing  
involved_in protein autoprocessing  
involved_in protein processing  
involved_in proteolysis  
involved_in response to misfolded protein  
involved_in response to misfolded protein  
involved_in zymogen activation  
involved_in zymogen activation  
involved_in zymogen activation  
Component Evidence Code Pubs
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
located_in extracellular space  
is_active_in rough endoplasmic reticulum  

General protein information

Preferred Names
coagulation factor XII
Names
factor XII
hageman factor
NP_001014028.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014006.1NP_001014028.1  coagulation factor XII precursor

    See identical proteins and their annotated locations for NP_001014028.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088187
    UniProtKB/TrEMBL
    A0A0H2UI19
    Related
    ENSRNOP00000061983.3, ENSRNOT00000066586.4
    Conserved Domains (7) summary
    smart00020
    Location:361597
    Tryp_SPc; Trypsin-like serine protease
    cd00054
    Location:95130
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:132170
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:4087
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00190
    Location:362600
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00008
    Location:177207
    EGF; EGF-like domain
    pfam00051
    Location:216294
    Kringle; Kringle domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    9212819..9220664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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