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Nsd1 nuclear receptor binding SET domain protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306764, updated on 13-Apr-2024

Summary

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Official Symbol
Nsd1provided by RGD
Official Full Name
nuclear receptor binding SET domain protein 1provided by RGD
Primary source
RGD:1307748
See related
Ensembl:ENSRNOG00000016680 AllianceGenome:RGD:1307748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including histone-lysine N-methyltransferase activity; nuclear receptor binding activity; and zinc ion binding activity. Predicted to be involved in histone methylation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within gastrulation with mouth forming second; regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity; and regulation of protein modification process. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in Sotos syndrome; Sotos syndrome 1; acute myeloid leukemia; microcephaly; and neuroblastoma. Orthologous to human NSD1 (nuclear receptor binding SET domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 292.0), Spleen (RPKM 243.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nsd1 in Genome Data Viewer
Location:
17p14
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9317085..9431528, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9311963..9426373, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9840859..9955391, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene PRELI domain containing 1 Neighboring gene RAB24, member RAS oncogene family Neighboring gene uncharacterized LOC134482677 Neighboring gene fibroblast growth factor receptor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia. Shiba N, et al. Genes Chromosomes Cancer, 2013 Jul. PMID 23630019
  2. Further Evidence of Contrasting Phenotypes Caused by Reciprocal Deletions and Duplications: Duplication of NSD1 Causes Growth Retardation and Microcephaly. Rosenfeld JA, et al. Mol Syndromol, 2013 Jan. PMID 23599694, Free PMC Article
  3. A transposon-based analysis of gene mutations related to skin cancer development. Quintana RM, et al. J Invest Dermatol, 2013 Jan. PMID 22832494
  4. Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Berdasco M, et al. Proc Natl Acad Sci U S A, 2009 Dec 22. PMID 20018718, Free PMC Article
  5. Familial gigantism caused by an NSD1 mutation. van Haelst MM, et al. Am J Med Genet A, 2005 Nov 15. PMID 16222665

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K36 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K36 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K20 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gastrulation with mouth forming second ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase, H3 lysine-36 specific
Names
histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
NP_001388465.1
XP_006253683.1
XP_006253684.1
XP_006253685.1
XP_006253686.1
XP_006253689.1
XP_008769713.1
XP_038951546.1
XP_038951547.1
XP_038951548.1
XP_038951549.1
XP_038951550.1
XP_038951551.1
XP_038951553.1
XP_063132407.1
XP_063132408.1
XP_063132409.1
XP_063132410.1
XP_063132411.1
XP_063132412.1
XP_063132413.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401536.1 → NP_001388465.1  histone-lysine N-methyltransferase, H3 lysine-36 specific

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8I6AMN8
    Related
    ENSRNOP00000094644.1, ENSRNOT00000118233.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    9317085..9431528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095620.2 → XP_038951548.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBL4, A6KAU7, D4AA06
    Conserved Domains (12) summary
    cd05837
    Location:50 → 160
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1483 → 1577
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03247
    Location:1952 → 2324
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:1183 → 1316
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1274 → 1316
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1321 → 1367
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1368 → 1421
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1438 → 1477
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1849 → 1891
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1670 → 1811
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1630 → 1668
    AWS; AWS domain
    pfam17982
    Location:1890 → 1939
    C5HCH; NSD Cys-His rich domain

  2. XM_006253624.5 → XP_006253686.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    See identical proteins and their annotated locations for XP_006253686.1

    UniProtKB/TrEMBL
    A0A8I6A1J6, A0A8I6AMN8, A6KAU6
    Conserved Domains (9) summary
    cd05837
    Location:319 → 429
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1752 → 1846
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1889 → 1939
    AWS; associated with SET domains
    smart00317
    Location:1940 → 2063
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15648
    Location:1543 → 1585
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1590 → 1636
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1637 → 1690
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1707 → 1746
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2118 → 2160
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

  3. XM_063276340.1 → XP_063132410.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBL4

  4. XM_063276337.1 → XP_063132407.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    UniProtKB/TrEMBL
    A0A8I6AMN8

  5. XM_039095619.2 → XP_038951547.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBL4, A6KAU7, D4AA06
    Related
    ENSRNOP00000077028.1
    Conserved Domains (12) summary
    cd05837
    Location:50 → 160
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1483 → 1577
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03247
    Location:1952 → 2324
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:1183 → 1316
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1274 → 1316
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1321 → 1367
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1368 → 1421
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1438 → 1477
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1849 → 1891
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1670 → 1811
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1630 → 1668
    AWS; AWS domain
    pfam17982
    Location:1890 → 1939
    C5HCH; NSD Cys-His rich domain

  6. XM_006253621.5 → XP_006253683.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    See identical proteins and their annotated locations for XP_006253683.1

    UniProtKB/TrEMBL
    A0A8I6A1J6, A0A8I6AMN8, A6KAU6
    Conserved Domains (9) summary
    cd05837
    Location:319 → 429
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1752 → 1846
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1889 → 1939
    AWS; associated with SET domains
    smart00317
    Location:1940 → 2063
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15648
    Location:1543 → 1585
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1590 → 1636
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1637 → 1690
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1707 → 1746
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2118 → 2160
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

  7. XM_063276341.1 → XP_063132411.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBL4

  8. XM_063276339.1 → XP_063132409.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    UniProtKB/TrEMBL
    A0A8I6AMN8

  9. XM_063276343.1 → XP_063132413.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBL4

  10. XM_063276338.1 → XP_063132408.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    UniProtKB/TrEMBL
    A0A8I6AMN8

  11. XM_006253623.4 → XP_006253685.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    See identical proteins and their annotated locations for XP_006253685.1

    UniProtKB/TrEMBL
    A0A8I6A1J6, A0A8I6AMN8, A6KAU6
    Conserved Domains (9) summary
    cd05837
    Location:319 → 429
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1752 → 1846
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1889 → 1939
    AWS; associated with SET domains
    smart00317
    Location:1940 → 2063
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15648
    Location:1543 → 1585
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1590 → 1636
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1637 → 1690
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1707 → 1746
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2118 → 2160
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

  12. XM_039095618.2 → XP_038951546.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBL4, A6KAU7, D4AA06
    Conserved Domains (12) summary
    cd05837
    Location:50 → 160
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1483 → 1577
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03247
    Location:1952 → 2324
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:1183 → 1316
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1274 → 1316
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1321 → 1367
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1368 → 1421
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1438 → 1477
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1849 → 1891
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1670 → 1811
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1630 → 1668
    AWS; AWS domain
    pfam17982
    Location:1890 → 1939
    C5HCH; NSD Cys-His rich domain

  13. XM_006253622.5 → XP_006253684.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    See identical proteins and their annotated locations for XP_006253684.1

    UniProtKB/TrEMBL
    A0A8I6A1J6, A0A8I6AMN8, A6KAU6
    Related
    ENSRNOP00000084557.1
    Conserved Domains (9) summary
    cd05837
    Location:319 → 429
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1752 → 1846
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1889 → 1939
    AWS; associated with SET domains
    smart00317
    Location:1940 → 2063
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15648
    Location:1543 → 1585
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1590 → 1636
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1637 → 1690
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1707 → 1746
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2118 → 2160
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

  14. XM_039095621.2 → XP_038951549.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBL4, A6KAU7, D4AA06
    Conserved Domains (12) summary
    cd05837
    Location:50 → 160
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1483 → 1577
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03247
    Location:1952 → 2324
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:1183 → 1316
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1274 → 1316
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1321 → 1367
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1368 → 1421
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1438 → 1477
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1849 → 1891
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1670 → 1811
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1630 → 1668
    AWS; AWS domain
    pfam17982
    Location:1890 → 1939
    C5HCH; NSD Cys-His rich domain

  15. XM_039095622.2 → XP_038951550.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBL4, A6KAU7, D4AA06
    Conserved Domains (12) summary
    cd05837
    Location:50 → 160
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1483 → 1577
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03247
    Location:1952 → 2324
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:1183 → 1316
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1274 → 1316
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1321 → 1367
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1368 → 1421
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1438 → 1477
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1849 → 1891
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1670 → 1811
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1630 → 1668
    AWS; AWS domain
    pfam17982
    Location:1890 → 1939
    C5HCH; NSD Cys-His rich domain

  16. XM_008771491.4 → XP_008769713.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    See identical proteins and their annotated locations for XP_008769713.1

    UniProtKB/TrEMBL
    A0A8I6A1J6, A0A8I6AMN8, A6KAU6
    Related
    ENSRNOP00000057648.2
    Conserved Domains (9) summary
    cd05837
    Location:319 → 429
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1752 → 1846
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1889 → 1939
    AWS; associated with SET domains
    smart00317
    Location:1940 → 2063
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15648
    Location:1543 → 1585
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1590 → 1636
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1637 → 1690
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1707 → 1746
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2118 → 2160
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

  17. XM_063276342.1 → XP_063132412.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBL4

  18. XM_039095623.2 → XP_038951551.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X3

    UniProtKB/TrEMBL
    A6KAU7, D4AA06
    Conserved Domains (12) summary
    cd05837
    Location:14 → 124
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1447 → 1541
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03247
    Location:1916 → 2288
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:1147 → 1280
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1238 → 1280
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1285 → 1331
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1332 → 1385
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1402 → 1441
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1813 → 1855
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1634 → 1775
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1594 → 1632
    AWS; AWS domain
    pfam17982
    Location:1854 → 1903
    C5HCH; NSD Cys-His rich domain

  19. XM_006253627.5 → XP_006253689.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X4

    See identical proteins and their annotated locations for XP_006253689.1

    Conserved Domains (9) summary
    cd05837
    Location:319 → 429
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1752 → 1846
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1889 → 1939
    AWS; associated with SET domains
    smart00317
    Location:1940 → 2063
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15648
    Location:1543 → 1585
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1590 → 1636
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1637 → 1690
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1707 → 1746
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cl22851
    Location:2118 → 2152
    PHD_SF; PHD finger superfamily

  20. XM_039095625.2 → XP_038951553.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X5

    Conserved Domains (1) summary
    cd05837
    Location:319 → 429
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107337.1: Suppressed sequence

    Description
    NM_001107337.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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