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Iars1 isoleucyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306804, updated on 13-Apr-2024

Summary

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Symbol
Iars1provided by RGD
Full Name
isoleucyl-tRNA synthetase 1provided by RGD
Primary source
RGD:621022
See related
Ensembl:ENSRNOG00000014616 AllianceGenome:RGD:621022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Iars; Iarsl
Summary
Predicted to enable GTPase binding activity and isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 158.2), Muscle (RPKM 135.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Iars1 in Genome Data Viewer
Location:
17p14
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (15147357..15193716, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (14940919..14987277, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (15356016..15402680, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene high mobility group protein B1-like Neighboring gene SPATA31 subfamily E, member 1 like 2 Neighboring gene uncharacterized LOC134482685 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene small nucleolar RNA SNORA84 Neighboring gene nucleolar protein 8 Neighboring gene centromere protein P Neighboring gene osteoglycin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. Shiba K, et al. Proc Natl Acad Sci U S A, 1994 Aug 2. PMID 8052601, Free PMC Article
  2. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, et al. Arterioscler Thromb Vasc Biol, 1999 Nov. PMID 10559001
  3. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Han JM, et al. Cell, 2012 Apr 13. PMID 22424946
  4. Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells. Kaminska M, et al. J Biol Chem, 2009 May 15. PMID 19289464, Free PMC Article
  5. Dissection of the structural organization of the aminoacyl-tRNA synthetase complex. Kaminska M, et al. J Biol Chem, 2009 Mar 6. PMID 19131329

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables isoleucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isoleucine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within isoleucyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in isoleucyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
isoleucine--tRNA ligase, cytoplasmic
Names
isoleucine--tRNA ligase, cytoplasmic-like
isoleucine-tRNA synthetase
isoleucyl tRNA synthetase
isoleucyl-tRNA synthetase, cytoplasmic
NP_001094042.1
XP_006253768.1
XP_008769755.1
XP_063132424.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100572.1 → NP_001094042.1  isoleucine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_001094042.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A1W2Q6K1, A6J6V4, F1LS86
    Related
    ENSRNOP00000019862.6, ENSRNOT00000019862.7
    Conserved Domains (3) summary
    cd07961
    Location:640 → 833
    Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
    cd00818
    Location:406 → 640
    IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
    PLN02882
    Location:6 → 1070
    PLN02882; aminoacyl-tRNA ligase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    15147357..15193716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253706.5 → XP_006253768.1  isoleucine--tRNA ligase, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_006253768.1

    UniProtKB/TrEMBL
    A0A1W2Q6K1, A6J6V4, F1LS86
    Conserved Domains (3) summary
    cd07961
    Location:640 → 833
    Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
    cd00818
    Location:406 → 640
    IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
    PLN02882
    Location:6 → 1070
    PLN02882; aminoacyl-tRNA ligase

  2. XM_008771533.4 → XP_008769755.1  isoleucine--tRNA ligase, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_008769755.1

    UniProtKB/TrEMBL
    A0A1W2Q6K1, A6J6V4, F1LS86
    Related
    ENSRNOP00000085677.1
    Conserved Domains (3) summary
    cd07961
    Location:640 → 833
    Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
    cd00818
    Location:406 → 640
    IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
    PLN02882
    Location:6 → 1070
    PLN02882; aminoacyl-tRNA ligase

  3. XM_063276354.1 → XP_063132424.1  isoleucine--tRNA ligase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A6J6V4, F1LS86
Nucleotide Protein Strain
Heading Accession and Version

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