U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Aspn asporin [ Rattus norvegicus (Norway rat) ]

Gene ID: 306805, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Symbol
Aspnprovided by RGD
Full Name
asporinprovided by RGD
Primary source
RGD:1549776
See related
Ensembl:ENSRNOG00000015410 AllianceGenome:RGD:1549776
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aspnl1
Summary
Predicted to enable calcium ion binding activity. Involved in response to fluoride. Located in cell projection. Human ortholog(s) of this gene implicated in ankylosing spondylitis; degenerative disc disease; and osteoarthritis. Orthologous to human ASPN (asporin). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: GeneIDs 103690027 and 306805 are annotated independently on Rnor_6.0 but may be redundant loci. [06 Feb 2015]
Expression
Biased expression in Heart (RPKM 139.2), Muscle (RPKM 96.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17p14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (15286338..15310567, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (15079910..15104369, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (14655958..14681355, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene osteoglycin Neighboring gene osteomodulin Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene ribosomal protein L6, pseudogene 6 Neighboring gene extracellular matrix protein 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Overexpression of PLAP-1 in bone marrow stromal cells inhibits the rat critical-size skull defect repair. Yu X, et al. J Mol Histol, 2015 Jun. PMID 26031659
  2. Overexpression of the PLAP-1 gene inhibits the differentiation of BMSCs into osteoblast-like cells. Sun J, et al. J Mol Histol, 2014 Oct. PMID 25038933
  3. Asporin and the mineralization process in fluoride-treated rats. Houari S, et al. J Bone Miner Res, 2014 Jun. PMID 24967458
  4. Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese. Shi D, et al. Arthritis Res Ther, 2011 Feb 17. PMID 21329514, Free PMC Article
  5. Association of an asporin repeat polymorphism with ankylosing spondylitis in Han Chinese population: a case-control study. Liu D, et al. Clin Invest Med, 2010 Feb 1. PMID 20144272

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of PLAP-1 in rat bone marrow stromal cells inhibits new bone formation and mineralization in rat critical-size skull defects in vivo.
    Title: Overexpression of PLAP-1 in bone marrow stromal cells inhibits the rat critical-size skull defect repair.
  2. Data suggest that transfected periodontal ligament-associated protein-1 (PLAP-1, asporin) has an inhibitory function in bone marrow stromal cells (rBMSCs) when they differentiate into osteoblast-like cells.
    Title: Overexpression of the PLAP-1 gene inhibits the differentiation of BMSCs into osteoblast-like cells.
  3. A model is proposed that predicts impaired mineral formation associated with the deficiency and excess of asporin.
    Title: Asporin and the mineralization process in fluoride-treated rats.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tooth mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to fluoride IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
asporin
Names
asporin-like 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014008.2 → NP_001014030.1  asporin precursor

    See identical proteins and their annotated locations for NP_001014030.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6J6W0, F7F5B0, M0R5F1, Q5XIH1
    Related
    ENSRNOP00000020704.4, ENSRNOT00000020704.6
    Conserved Domains (4) summary
    smart00013
    Location:70 → 99
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:141 → 347
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:79 → 98
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:100 → 157
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    15286338..15310567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253695.5 → XP_006253757.1  asporin isoform X1

    See identical proteins and their annotated locations for XP_006253757.1

    UniProtKB/TrEMBL
    A6J6W0, F7F5B0, M0R5F1, Q5XIH1
    Conserved Domains (4) summary
    smart00013
    Location:70 → 99
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:141 → 347
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:79 → 98
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:100 → 157
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous