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Dek DEK proto-oncogene [ Rattus norvegicus (Norway rat) ]

Gene ID: 306817, updated on 11-Apr-2024

Summary

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Official Symbol
Dekprovided by RGD
Official Full Name
DEK proto-oncogeneprovided by RGD
Primary source
RGD:1303246
See related
Ensembl:ENSRNOG00000016152 AllianceGenome:RGD:1303246
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone binding activity. Predicted to be involved in regulation of double-strand break repair. Predicted to act upstream of or within regulation of double-strand break repair via nonhomologous end joining. Predicted to be located in contractile fiber and nucleoplasm. Predicted to be active in nucleus. Orthologous to human DEK (DEK proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 475.8), Spleen (RPKM 442.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dek in Genome Data Viewer
Location:
17p14
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (17786989..17809096)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (17580804..17602825)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (17965872..17987836)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097909 Neighboring gene ring finger protein 144B Neighboring gene small nucleolar RNA U13 Neighboring gene lysine demethylase 1B Neighboring gene NLR family, pyrin domain containing 4E like, pseudogene 1 Neighboring gene thiopurine S-methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The human DEK oncogene regulates DNA damage response signaling and repair. Kavanaugh GM, et al. Nucleic Acids Res, 2011 Sep 1. PMID 21653549, Free PMC Article
  2. Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. Hollenbach AD, et al. J Cell Sci, 2002 Aug 15. PMID 12140263
  3. Maintenance of muscle stem-cell quiescence by microRNA-489. Cheung TH, et al. Nature, 2012 Feb 23. PMID 22358842, Free PMC Article
  4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94795

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair via nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of B-WICH complex IEA
Inferred from Electronic Annotation
more info
  
part_of B-WICH complex ISO
Inferred from Sequence Orthology
more info
  
located_in contractile muscle fiber IEA
Inferred from Electronic Annotation
more info
  
located_in contractile muscle fiber ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein DEK
Names
DEK oncogene (DNA binding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004255.1 → NP_001004255.1  protein DEK

    See identical proteins and their annotated locations for NP_001004255.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079344
    UniProtKB/Swiss-Prot
    Q6AXS3
    UniProtKB/TrEMBL
    A0A8I6A9D8, A6J702
    Related
    ENSRNOP00000021751.4, ENSRNOT00000021751.5
    Conserved Domains (2) summary
    smart00513
    Location:151 → 185
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam08766
    Location:323 → 377
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    17786989..17809096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276370.1 → XP_063132440.1  protein DEK isoform X1

  2. XM_063276371.1 → XP_063132441.1  protein DEK isoform X1

  3. XM_039095669.2 → XP_038951597.1  protein DEK isoform X2

    UniProtKB/Swiss-Prot
    Q6AXS3
    UniProtKB/TrEMBL
    A0A8I6A9D8, A6J702
    Conserved Domains (2) summary
    smart00513
    Location:151 → 185
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam08766
    Location:323 → 377
    DEK_C; DEK C terminal domain

  4. XM_063276372.1 → XP_063132442.1  protein DEK isoform X3

  5. XM_039095670.2 → XP_038951598.1  protein DEK isoform X4

    Conserved Domains (2) summary
    smart00513
    Location:82 → 116
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam08766
    Location:254 → 308
    DEK_C; DEK C terminal domain

RNA

  1. XR_010058862.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXS3.1 GenPept UniProtKB/Swiss-Prot:Q6AXS3

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