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Phactr1 phosphatase and actin regulator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306844, updated on 2-May-2024

Summary

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Symbol
Phactr1provided by RGD
Full Name
phosphatase and actin regulator 1provided by RGD
Primary source
RGD:1303187
See related
Ensembl:ENSRNOG00000014264 AllianceGenome:RGD:1303187
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein phosphatase 1 binding activity. Involved in regulation of phosphorylation. Located in synapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 70. Orthologous to human PHACTR1 (phosphatase and actin regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 252.9), Lung (RPKM 90.8) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Phactr1 in Genome Data Viewer
Location:
17p14-p12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (21769006..22246227, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (21560364..22040166, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (23245423..23761207)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547830 Neighboring gene eukaryotic translation initiation factor 1-like Neighboring gene uncharacterized LOC134482703 Neighboring gene TBC1 domain family, member 7 Neighboring gene uncharacterized LOC134482770 Neighboring gene uncharacterized LOC120097835 Neighboring gene Jupiter microtubule associated 1, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression. Kelloniemi A, et al. PLoS One, 2015. PMID 26098115, Free PMC Article
  2. De novo PHACTR1 mutations in West syndrome and their pathophysiological effects. Hamada N, et al. Brain, 2018 Nov 1. PMID 30256902
  3. G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly. Wiezlak M, et al. J Cell Sci, 2012 Dec 1. PMID 22976292
  4. Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Allen PB, et al. Proc Natl Acad Sci U S A, 2004 May 4. PMID 15107502, Free PMC Article
  5. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phactr1 seems to regulate the skeletal to cardiac alpha-actin isoform ratio.
    Title: The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC112561

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables actin binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein phosphatase 1 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actomyosin structure organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
  
involved_in cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cerebral cortex development IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebral cortex development ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebral cortex development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendrite arborization IEA
Inferred from Electronic Annotation
more info
  
involved_in dendrite arborization ISO
Inferred from Sequence Orthology
more info
  
involved_in dendrite arborization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of modification of postsynaptic structure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of modification of postsynaptic structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stress fiber assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatase and actin regulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214457.2 → NP_999622.2  phosphatase and actin regulator 1

    See identical proteins and their annotated locations for NP_999622.2

    Status: PROVISIONAL

    Source sequence(s)
    BC098634
    UniProtKB/TrEMBL
    A0A8I6ATP4
    Related
    ENSRNOP00000097958.1, ENSRNOT00000110352.1
    Conserved Domains (2) summary
    smart00707
    Location:461 → 485
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    21769006..22246227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095677.2 → XP_038951605.1  phosphatase and actin regulator 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5XW51, A6J754
    Conserved Domains (2) summary
    smart00707
    Location:530 → 554
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat

  2. XM_063276382.1 → XP_063132452.1  phosphatase and actin regulator 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6ATP4

  3. XM_063276381.1 → XP_063132451.1  phosphatase and actin regulator 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5XW51, A6J754

  4. XM_039095676.2 → XP_038951604.1  phosphatase and actin regulator 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5XW51, A6J754
    Related
    ENSRNOP00000077447.1
    Conserved Domains (2) summary
    smart00707
    Location:530 → 554
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat

  5. XM_039095681.2 → XP_038951609.1  phosphatase and actin regulator 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6ATP4
    Conserved Domains (2) summary
    smart00707
    Location:461 → 485
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat

  6. XM_039095678.2 → XP_038951606.1  phosphatase and actin regulator 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5XW51, A6J754
    Conserved Domains (2) summary
    smart00707
    Location:530 → 554
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:140 → 161
    RPEL; RPEL repeat

  7. XM_063276384.1 → XP_063132454.1  phosphatase and actin regulator 1 isoform X8

  8. XM_039095683.2 → XP_038951611.1  phosphatase and actin regulator 1 isoform X6

    Conserved Domains (2) summary
    smart00707
    Location:438 → 462
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:48 → 69
    RPEL; RPEL repeat

  9. XM_063276383.1 → XP_063132453.1  phosphatase and actin regulator 1 isoform X5

  10. XM_039095679.2 → XP_038951607.1  phosphatase and actin regulator 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZKJ8
    Related
    ENSRNOP00000078261.1
    Conserved Domains (2) summary
    smart00707
    Location:524 → 548
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:134 → 155
    RPEL; RPEL repeat

  11. XM_039095680.2 → XP_038951608.1  phosphatase and actin regulator 1 isoform X3

    Conserved Domains (2) summary
    smart00707
    Location:482 → 506
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:92 → 113
    RPEL; RPEL repeat

  12. XM_039095685.2 → XP_038951613.1  phosphatase and actin regulator 1 isoform X7

    UniProtKB/TrEMBL
    F1LNB2
    Related
    ENSRNOP00000043053.5
    Conserved Domains (2) summary
    smart00707
    Location:413 → 437
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:92 → 113
    RPEL; RPEL repeat

  13. XM_039095684.2 → XP_038951612.1  phosphatase and actin regulator 1 isoform X6

    Conserved Domains (2) summary
    smart00707
    Location:438 → 462
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:48 → 69
    RPEL; RPEL repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62024.1 GenPept UniProtKB/Swiss-Prot:P62024

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