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Btn2a2 butyrophilin, subfamily 2, member A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306957, updated on 13-Apr-2024

Summary

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Official Symbol
Btn2a2provided by RGD
Official Full Name
butyrophilin, subfamily 2, member A2provided by RGD
Primary source
RGD:1306973
See related
Ensembl:ENSRNOG00000038877 AllianceGenome:RGD:1306973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and negative regulation of cytokine production. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of signal transduction; and regulation of T cell activation. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Orthologous to several human genes including BTN2A2 (butyrophilin subfamily 2 member A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 29.6), Kidney (RPKM 20.6) and 8 other tissues See more
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Genomic context

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See Btn2a2 in Genome Data Viewer
Location:
17p11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (42048842..42060650)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (41620807..41632621)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (43867243..43878734)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482713 Neighboring gene transfer RNA arginine (anticodon ACG) 4 Neighboring gene transfer RNA tryptophan (anticodon CCA) 8 Neighboring gene transfer RNA glutamic acid (anticodon UUC) 10 Neighboring gene butyrophilin, subfamily 1, member A1 Neighboring gene transfer RNA leucine (anticodon CAG) 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes. Ammann JU, et al. J Immunol, 2013 May 15. PMID 23589618, Free PMC Article
  2. BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation. Smith IA, et al. J Immunol, 2010 Apr 1. PMID 20208008
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
butyrophilin subfamily 2 member A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408693.1 → NP_001395622.1  butyrophilin subfamily 2 member A2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    D4A076
    Related
    ENSRNOP00000056159.3, ENSRNOT00000059403.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    42048842..42060650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096234.2 → XP_038952162.1  butyrophilin subfamily 2 member A2 isoform X3

    Conserved Domains (1) summary
    cl02614
    Location:191 → 361
    SPRY; SPRY domain

  2. XM_063276440.1 → XP_063132510.1  butyrophilin subfamily 2 member A2 isoform X1

  3. XM_063276441.1 → XP_063132511.1  butyrophilin subfamily 2 member A2 isoform X2

  4. XM_039096235.2 → XP_038952163.1  butyrophilin subfamily 2 member A2 isoform X4

    Conserved Domains (1) summary
    cd05713
    Location:31 → 144
    IgV_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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