H2bc8 H2B clustered histone 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: H2bc8provided by RGD
Official Full Name: H2B clustered histone 8provided by RGD
Primary source: RGD:1308088
See related: AllianceGenome:RGD:1308088
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hist1h2bf; Hist1h2bl; Hist1h2bp
Summary: Predicted to enable DNA binding activity and identical protein binding activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to other organism; and nucleosome assembly. Predicted to be located in cytosol; extracellular space; and nucleoplasm. Predicted to be part of nucleosome. Orthologous to human H2BC13 (H2B clustered histone 13) and H2BC4 (H2B clustered histone 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 17p11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (47404405..47405155)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (42708658..42709408)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (44748445..44748910)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Hist1h2bc (e-PCR), detects polymorphism
- UniSTS:259084

UniSTS:487785 (e-PCR)
- UniSTS:487785

UniSTS:488584 (e-PCR)
- UniSTS:488584

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone cluster 1 H2B family member l

Names: histone 1, H2bp; histone H2B type 1; histone H2B type 1-C/E/F/G/I; histone cluster 1, H2bf; histone cluster 1, H2bl; histone cluster 1, H2bp

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.