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Larp4b La ribonucleoprotein 4B [ Rattus norvegicus (Norway rat) ]

Gene ID: 307070, updated on 3-Apr-2024

Summary

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Official Symbol
Larp4bprovided by RGD
Official Full Name
La ribonucleoprotein 4Bprovided by RGD
Primary source
RGD:1310713
See related
Ensembl:ENSRNOG00000015888 AllianceGenome:RGD:1310713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Larp5; RGD1310713
Summary
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in positive regulation of 3'-UTR-mediated mRNA stabilization and positive regulation of translation. Predicted to be located in nucleolus and polysomal ribosome. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human LARP4B (La ribonucleoprotein 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 242.7), Adrenal (RPKM 239.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Larp4b in Genome Data Viewer
Location:
17q12.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (65813125..65908920, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (61138663..61217423, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (63236007..63317298)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene disco-interacting protein 2 homolog C Neighboring gene acireductone dioxygenase 1, pseudogene 1 Neighboring gene 60S ribosomal protein L22-like Neighboring gene uncharacterized LOC120097870 Neighboring gene GTP binding protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A stimulatory role for the La-related protein 4B in translation. Schäffler K, et al. RNA, 2010 Aug. PMID 20573744, Free PMC Article
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
la-related protein 4B
Names
La ribonucleoprotein domain family, member 4B
La ribonucleoprotein domain family, member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107361.2 → NP_001100831.1  la-related protein 4B

    See identical proteins and their annotated locations for NP_001100831.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6KN12
    Conserved Domains (2) summary
    cd08036
    Location:157 → 231
    LARP_5; La RNA-binding domain of La-related protein 5
    cl17169
    Location:236 → 312
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    65813125..65908920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276485.1 → XP_063132555.1  la-related protein 4B isoform X4

    UniProtKB/TrEMBL
    A6KN12

  2. XM_063276484.1 → XP_063132554.1  la-related protein 4B isoform X3

    UniProtKB/TrEMBL
    D3ZF45

  3. XM_063276489.1 → XP_063132559.1  la-related protein 4B isoform X11

  4. XM_039095756.2 → XP_038951684.1  la-related protein 4B isoform X1

    Conserved Domains (2) summary
    cd08036
    Location:180 → 254
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:259 → 335
    RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

  5. XM_063276490.1 → XP_063132560.1  la-related protein 4B isoform X13

  6. XM_039095764.2 → XP_038951692.1  la-related protein 4B isoform X11

    Conserved Domains (2) summary
    cd08036
    Location:157 → 231
    LARP_5; La RNA-binding domain of La-related protein 5
    cl17169
    Location:236 → 312
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. XM_063276488.1 → XP_063132558.1  la-related protein 4B isoform X8

  8. XM_063276487.1 → XP_063132557.1  la-related protein 4B isoform X7

    UniProtKB/TrEMBL
    A0A8I6A8U8

  9. XM_039095758.2 → XP_038951686.1  la-related protein 4B isoform X3

    UniProtKB/TrEMBL
    D3ZF45
    Related
    ENSRNOP00000055347.4
    Conserved Domains (2) summary
    cd08036
    Location:157 → 231
    LARP_5; La RNA-binding domain of La-related protein 5
    cl17169
    Location:236 → 312
    RRM_SF; RNA recognition motif (RRM) superfamily

  10. XM_039095763.2 → XP_038951691.1  la-related protein 4B isoform X12

    Conserved Domains (2) summary
    cd08036
    Location:180 → 254
    LARP_5; La RNA-binding domain of La-related protein 5
    cl17169
    Location:259 → 335
    RRM_SF; RNA recognition motif (RRM) superfamily

  11. XM_039095762.2 → XP_038951690.1  la-related protein 4B isoform X10

    Conserved Domains (2) summary
    cd08036
    Location:180 → 254
    LARP_5; La RNA-binding domain of La-related protein 5
    cl17169
    Location:259 → 335
    RRM_SF; RNA recognition motif (RRM) superfamily

  12. XM_039095761.2 → XP_038951689.1  la-related protein 4B isoform X9

    Conserved Domains (2) summary
    cd08036
    Location:180 → 254
    LARP_5; La RNA-binding domain of La-related protein 5
    cl17169
    Location:259 → 335
    RRM_SF; RNA recognition motif (RRM) superfamily

  13. XM_063276486.1 → XP_063132556.1  la-related protein 4B isoform X6

  14. XM_039095760.2 → XP_038951688.1  la-related protein 4B isoform X5

    Related
    ENSRNOP00000089771.1
    Conserved Domains (2) summary
    cd08036
    Location:180 → 254
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:259 → 335
    RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

  15. XM_039095757.2 → XP_038951685.1  la-related protein 4B isoform X2

    UniProtKB/TrEMBL
    A0A0G2K4I2
    Related
    ENSRNOP00000073054.2
    Conserved Domains (2) summary
    cd08036
    Location:180 → 254
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:259 → 335
    RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

  16. XM_039095755.2 → XP_038951683.1  la-related protein 4B isoform X1

    Conserved Domains (2) summary
    cd08036
    Location:180 → 254
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:259 → 335
    RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

RNA

  1. XR_010058882.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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