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Mastl microtubule associated serine/threonine kinase-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 307169, updated on 11-Apr-2024

Summary

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Symbol
Mastlprovided by RGD
Full Name
microtubule associated serine/threonine kinase-likeprovided by RGD
Primary source
RGD:1309186
See related
Ensembl:ENSRNOG00000054474 AllianceGenome:RGD:1309186
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including meiotic chromosome condensation; negative regulation of phosphoprotein phosphatase activity; and regulation of meiotic cell cycle. Predicted to act upstream of or within female meiosis II and positive regulation of ubiquitin protein ligase activity. Predicted to be located in cleavage furrow; microtubule cytoskeleton; and nucleoplasm. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human MASTL (microtubule associated serine/threonine kinase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 68.8), Spleen (RPKM 37.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mastl in Genome Data Viewer
Location:
17q12.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (90158592..90195550, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (85250512..85287479, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (89839562..89875855)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26, pseudogene 1 Neighboring gene acyl-CoA binding domain containing 5 Neighboring gene YME1-like 1 ATPase Neighboring gene POTE ankyrin domain family, member C Neighboring gene ankyrin repeat domain-containing protein 26-like Neighboring gene sperm motility kinase X-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Greatwall kinase is required for meiotic maturation in porcine oocytes. Li YH, et al. Biol Reprod, 2013 Sep. PMID 23843240
  2. MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis. Voets E, et al. Cell Cycle, 2010 Sep 1. PMID 20818157
  3. Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance. Burgess A, et al. Proc Natl Acad Sci U S A, 2010 Jul 13. PMID 20538976, Free PMC Article
  4. FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10. Gandhi MJ, et al. Hum Hered, 2003. PMID 12890928
  5. Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II. Adhikari D, et al. J Cell Biol, 2014 Sep 29. PMID 25246615, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within female meiosis II ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in meiotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase greatwall
Names
microtubule-associated serine/threonine-protein kinase-like
serine/threonine-protein kinase greatwall-like
NP_001100839.1
XP_006254402.1
XP_006254403.1
XP_063132572.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107369.1 → NP_001100839.1  serine/threonine-protein kinase greatwall

    See identical proteins and their annotated locations for NP_001100839.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474100
    UniProtKB/TrEMBL
    A6KRZ2, D4A355
    Related
    ENSRNOP00000074792.1, ENSRNOT00000077899.2
    Conserved Domains (3) summary
    smart00220
    Location:34 → 194
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05610
    Location:29 → 222
    STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
    cl21453
    Location:659 → 857
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    90158592..90195550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276502.1 → XP_063132572.1  serine/threonine-protein kinase greatwall isoform X3

  2. XM_006254341.5 → XP_006254403.1  serine/threonine-protein kinase greatwall isoform X2

    UniProtKB/TrEMBL
    D4A355
    Conserved Domains (2) summary
    smart00220
    Location:34 → 148
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:613 → 812
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006254340.5 → XP_006254402.1  serine/threonine-protein kinase greatwall isoform X1

    UniProtKB/TrEMBL
    D4A355
    Conserved Domains (3) summary
    smart00220
    Location:34 → 194
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05610
    Location:29 → 222
    STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
    cl21453
    Location:659 → 858
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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