Neto1 neuropilin and tolloid like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Neto1provided by RGD
Official Full Name: neuropilin and tolloid like 1provided by RGD
Primary source: RGD:1566269
See related: Ensembl:ENSRNOG00000014006 AllianceGenome:RGD:1566269
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566269
Summary: Predicted to enable ionotropic glutamate receptor binding activity. Predicted to be involved in learning or memory; regulation of kainate selective glutamate receptor activity; and regulation of long-term neuronal synaptic plasticity. Predicted to act upstream of or within positive regulation of excitatory postsynaptic potential and receptor localization to synapse. Predicted to be located in excitatory synapse and postsynaptic density membrane. Predicted to be active in glutamatergic synapse. Predicted to be integral component of postsynaptic density membrane. Orthologous to human NETO1 (neuropilin and tolloid like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 85.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (81905455..82028730)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (79635633..79753913)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (83471342..83585043)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NETO1 and Gluk1 specifically promote dendritic growth of interneurons in the visual cortex.
Title: Development of Cortical Pyramidal Cell and Interneuronal Dendrites: a Role for Kainate Receptor Subunits and NETO1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18Got77 (e-PCR)
- UniSTS:113314

D18Mit6 (e-PCR), detects polymorphism
- UniSTS:119534

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde axonal transport of neurotransmitter receptor complex	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within receptor localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuropilin and tolloid-like protein 1

Names: neuropilin (NRP) and tolloid (TLL)-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107371.1 → NP_001100841.1 neuropilin and tolloid-like protein 1 precursor

See identical proteins and their annotated locations for NP_001100841.1

Status: PROVISIONAL

Source sequence(s)

CH474021

UniProtKB/TrEMBL

A6K5M8, D4AAD6

Related

ENSRNOP00000019384.4, ENSRNOT00000019384.5

Conserved Domains (2) summary

cd00041
Location:51 → 154

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cl00104
Location:291 → 326

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

81905455..82028730

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255035.5 → XP_006255097.1 neuropilin and tolloid-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_006255097.1

UniProtKB/TrEMBL

A6K5M8, D4AAD6

Conserved Domains (2) summary

cd00041
Location:51 → 154

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cl00104
Location:291 → 326

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039096765.2 → XP_038952693.1 neuropilin and tolloid-like protein 1 isoform X1

UniProtKB/TrEMBL

A6K5M8, D4AAD6

Conserved Domains (2) summary

cd00041
Location:51 → 154

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cl00104
Location:291 → 326

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039096766.2 → XP_038952694.1 neuropilin and tolloid-like protein 1 isoform X2

Conserved Domains (2) summary

cd00041
Location:51 → 154

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cl00104
Location:158 → 193

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_063277287.1 → XP_063133357.1 neuropilin and tolloid-like protein 1 isoform X1

UniProtKB/TrEMBL

A6K5M8, D4AAD6
XM_063277288.1 → XP_063133358.1 neuropilin and tolloid-like protein 1 isoform X5
XM_039096769.2 → XP_038952697.1 neuropilin and tolloid-like protein 1 isoform X7

Conserved Domains (1) summary

cd00041
Location:51 → 154

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
XM_008772133.4 → XP_008770355.1 neuropilin and tolloid-like protein 1 isoform X6

Conserved Domains (1) summary

cd00041
Location:51 → 154

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
XM_039096768.2 → XP_038952696.1 neuropilin and tolloid-like protein 1 isoform X4

Conserved Domains (2) summary

cl00049
Location:16 → 90

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cl00104
Location:95 → 130

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039096767.1 → XP_038952695.1 neuropilin and tolloid-like protein 1 isoform X3

Conserved Domains (2) summary

cd00041
Location:25 → 111

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cl00104
Location:116 → 151

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...