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Ark2n arkadia (RNF111) N-terminal like PKA signaling regulator 2N [ Rattus norvegicus (Norway rat) ]

Gene ID: 307249, updated on 26-Apr-2024

Summary

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Official Symbol
Ark2nprovided by RGD
Official Full Name
arkadia (RNF111) N-terminal like PKA signaling regulator 2Nprovided by RGD
Primary source
RGD:1308601
See related
Ensembl:ENSRNOG00000017215 AllianceGenome:RGD:1308601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308601
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Orthologous to human C18orf25 (chromosome 18 open reading frame 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 240.3), Heart (RPKM 196.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ark2n in Genome Data Viewer
Location:
18q12.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (73431104..73520759, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (71155956..71243655, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (74012965..74059618, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348739 Neighboring gene uncharacterized LOC102551968 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene HAUS augmin-like complex, subunit 1 Neighboring gene ATP synthase F1 subunit alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of viral life cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein ARK2N
Names
arkadia N-terminal like PKA signaling regulator 2N
uncharacterized protein C18orf25 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107374.2 → NP_001100844.1  protein ARK2N

    See identical proteins and their annotated locations for NP_001100844.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6KMV4, D4A3X1
    Related
    ENSRNOP00000035406.4, ENSRNOT00000038767.6
    Conserved Domains (1) summary
    pfam15303
    Location:67 → 238
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    73431104..73520759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277296.1 → XP_063133366.1  protein ARK2N isoform X2

    UniProtKB/TrEMBL
    A0A8I6GF24, A6KMV3

  2. XM_039096776.2 → XP_038952704.1  protein ARK2N isoform X1

    UniProtKB/TrEMBL
    A6KMV4, D4A3X1
    Conserved Domains (1) summary
    pfam15303
    Location:67 → 238
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

  3. XM_039096777.2 → XP_038952705.1  protein ARK2N isoform X2

    UniProtKB/TrEMBL
    A0A8I6GF24, A6KMV3
    Related
    ENSRNOP00000086540.1
    Conserved Domains (1) summary
    pfam15303
    Location:67 → 238
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
Nucleotide Protein Strain
Heading Accession and Version

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