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Dmxl1 Dmx-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307429, updated on 13-Apr-2024

Summary

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Official Symbol
Dmxl1provided by RGD
Official Full Name
Dmx-like 1provided by RGD
Primary source
RGD:1307692
See related
Ensembl:ENSRNOG00000024671 AllianceGenome:RGD:1307692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in vacuolar acidification. Predicted to be part of RAVE complex. Orthologous to human DMXL1 (Dmx like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 420.4), Thymus (RPKM 326.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dmxl1 in Genome Data Viewer
Location:
18q11
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (45179505..45349999)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (42993292..43163457)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (44468762..44644769)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098148 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ribosomal protein L15, pseudogene 11 Neighboring gene uncharacterized LOC120098294 Neighboring gene TNF alpha induced protein 8 Neighboring gene uncharacterized LOC120098293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RAVE complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dmX-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107388.2 → NP_001100858.2  dmX-like protein 1

    Status: VALIDATED

    Source sequence(s)
    FQ200391, JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6A9G2, A6IWZ8
    Related
    ENSRNOP00000088454.1, ENSRNOT00000094956.1
    Conserved Domains (3) summary
    sd00039
    Location:2790 → 2835
    7WD40; WD40 repeat [structural motif]
    pfam12234
    Location:1141 → 1876
    Rav1p_C; RAVE protein 1 C terminal
    cl29593
    Location:2746 → 3003
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    45179505..45349999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601109.3 → XP_017456598.1  dmX-like protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A9G2

  2. XM_006254710.5 → XP_006254772.1  dmX-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006254772.1

    UniProtKB/TrEMBL
    A0A8I6A9G2
    Conserved Domains (4) summary
    COG2319
    Location:2838 → 3080
    WD40; WD40 repeat [General function prediction only]
    pfam12234
    Location:1141 → 1876
    Rav1p_C; RAVE protein 1 C terminal
    sd00039
    Location:2849 → 2894
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:2805 → 3062
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_006254711.5 → XP_006254773.1  dmX-like protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006254773.1

    UniProtKB/TrEMBL
    A0A8I5ZU67, A0A8I6A9G2
    Related
    ENSRNOP00000082026.1
    Conserved Domains (4) summary
    COG2319
    Location:2817 → 3059
    WD40; WD40 repeat [General function prediction only]
    pfam12234
    Location:1141 → 1876
    Rav1p_C; RAVE protein 1 C terminal
    sd00039
    Location:2828 → 2873
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:2784 → 3041
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_006254712.5 → XP_006254774.1  dmX-like protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006254774.1

    UniProtKB/TrEMBL
    A0A8I6A9G2, D4AA13
    Related
    ENSRNOP00000033699.4
    Conserved Domains (4) summary
    COG2319
    Location:2800 → 3042
    WD40; WD40 repeat [General function prediction only]
    pfam12234
    Location:1141 → 1876
    Rav1p_C; RAVE protein 1 C terminal
    sd00039
    Location:2811 → 2856
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:2767 → 3024
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

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