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Mcc MCC regulator of WNT signaling pathway [ Rattus norvegicus (Norway rat) ]

Gene ID: 307449, updated on 3-Apr-2024

Summary

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Symbol
Mccprovided by RGD
Full Name
MCC regulator of WNT signaling pathwayprovided by RGD
Primary source
RGD:1561988
See related
Ensembl:ENSRNOG00000011271 AllianceGenome:RGD:1561988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561988
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial cell migration; and negative regulation of epithelial cell proliferation. Predicted to be located in several cellular components, including cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human MCC (MCC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 152.2), Liver (RPKM 135.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18q11
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (37042350..37517114, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (36794206..37266237, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (12006663..12128849)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (35683185..35817117, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene S-phase kinase-associated protein 1, pseudogene 1 Neighboring gene decapping mRNA 2 Neighboring gene YTH N6-methyladenosine RNA binding protein C2 Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription. Fukuyama R, et al. Oncogene, 2008 Oct 9. PMID 18591935, Free PMC Article
  2. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Kinzler KW, et al. Science, 1991 Mar 15. PMID 1848370
  3. MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm. Pangon L, et al. Int J Cancer, 2015 Jan 1. PMID 24824780
  4. MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells. Arnaud C, et al. FEBS Lett, 2009 Jul 21. PMID 19555689
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
colorectal mutant cancer protein
Names
MCC, WNT signaling pathway regulator
mutated in colorectal cancers

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170534.2 → NP_001164005.2  colorectal mutant cancer protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    F1LZS6
    Related
    ENSRNOP00000073806.2, ENSRNOT00000079667.2
    Conserved Domains (5) summary
    COG1196
    Location:188 → 992
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:24 → 80
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam10506
    Location:577 → 640
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
    pfam13499
    Location:25 → 78
    EF-hand_7; EF-hand domain pair
    cl23720
    Location:207 → 309
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    37042350..37517114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096842.2 → XP_038952770.1  colorectal mutant cancer protein isoform X1

    Conserved Domains (4) summary
    COG1196
    Location:777 → 1036
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:209 → 473
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10506
    Location:621 → 685
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
    pfam13499
    Location:50 → 106
    EF-hand_7; EF-hand domain pair

  2. XM_039096845.2 → XP_038952773.1  colorectal mutant cancer protein isoform X3

    UniProtKB/TrEMBL
    F1LZS6
    Conserved Domains (3) summary
    COG1196
    Location:703 → 962
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:135 → 399
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10506
    Location:547 → 611
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

  3. XM_039096844.2 → XP_038952772.1  colorectal mutant cancer protein isoform X3

    UniProtKB/TrEMBL
    F1LZS6
    Conserved Domains (3) summary
    COG1196
    Location:703 → 962
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:135 → 399
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10506
    Location:547 → 611
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

  4. XM_063277360.1 → XP_063133430.1  colorectal mutant cancer protein isoform X4

  5. XM_039096843.2 → XP_038952771.1  colorectal mutant cancer protein isoform X2

    UniProtKB/TrEMBL
    A0A0G2K6G7
    Conserved Domains (3) summary
    COG1196
    Location:216 → 1020
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam10506
    Location:605 → 669
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
    pfam13499
    Location:50 → 106
    EF-hand_7; EF-hand domain pair

  6. XM_039096841.2 → XP_038952769.1  colorectal mutant cancer protein isoform X1

    Conserved Domains (4) summary
    COG1196
    Location:777 → 1036
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:209 → 473
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10506
    Location:621 → 685
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
    pfam13499
    Location:50 → 106
    EF-hand_7; EF-hand domain pair

  7. XM_063277361.1 → XP_063133431.1  colorectal mutant cancer protein isoform X7

    UniProtKB/TrEMBL
    A0A0G2K098, A6KUB9

  8. XM_039096846.2 → XP_038952774.1  colorectal mutant cancer protein isoform X5

    UniProtKB/TrEMBL
    F1LZS6
    Related
    ENSRNOP00000071358.2
    Conserved Domains (3) summary
    COG1196
    Location:574 → 833
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:14 → 270
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10506
    Location:418 → 482
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

  9. XM_039096848.2 → XP_038952776.1  colorectal mutant cancer protein isoform X8

    UniProtKB/TrEMBL
    A6KUC0
    Conserved Domains (2) summary
    COG1196
    Location:511 → 770
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam10506
    Location:355 → 419
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

  10. XM_039096847.2 → XP_038952775.1  colorectal mutant cancer protein isoform X6

    UniProtKB/TrEMBL
    F1LZS6
    Related
    ENSRNOP00000015172.8
    Conserved Domains (2) summary
    COG1196
    Location:569 → 828
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam10506
    Location:413 → 477
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

  11. XM_039096849.2 → XP_038952777.1  colorectal mutant cancer protein isoform X8

    UniProtKB/TrEMBL
    A6KUC0
    Conserved Domains (2) summary
    COG1196
    Location:511 → 770
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam10506
    Location:355 → 419
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001145833.1: Suppressed sequence

    Description
    NM_001145833.1: This RefSeq was permanently suppressed because the CDS was partial and represents a different locus.
Nucleotide Protein Strain
Heading Accession and Version

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