Dsc3 desmocollin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dsc3provided by RGD
Official Full Name: desmocollin 3provided by RGD
Primary source: RGD:1311782
See related: Ensembl:ENSRNOG00000017159 AllianceGenome:RGD:1311782
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity and gamma-catenin binding activity. Predicted to be involved in cell-cell adhesion and protein stabilization. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in several cellular components, including cell junction; extracellular region; and plasma membrane. Predicted to be active in desmosome. Orthologous to human DSC3 (desmocollin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 38.9), Lung (RPKM 16.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (11654833..11688871, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (11379759..11413797, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (11753047..11789846, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in desmosome	IBA Inferred from Biological aspect of Ancestor more info
located_in desmosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: desmocollin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107402.1 → NP_001100872.1 desmocollin-3

See identical proteins and their annotated locations for NP_001100872.1

Status: PROVISIONAL

Source sequence(s)

CH473974

UniProtKB/TrEMBL

A0A0G2K230, A6J2F2, D3ZZI6

Related

ENSRNOP00000072083.2, ENSRNOT00000077304.2

Conserved Domains (5) summary

cd11304
Location:251 → 355

Cadherin_repeat; Cadherin tandem repeat domain

smart01055
Location:33 → 115

Cadherin_pro; Cadherin prodomain like

pfam00028
Location:144 → 238

Cadherin; Cadherin domain

pfam01049
Location:851 → 895

Cadherin_C; Cadherin cytoplasmic region

cl09101
Location:599 → 674

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus