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Plekhg4 pleckstrin homology and RhoGEF domain containing G4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307796, updated on 3-Apr-2024

Summary

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Official Symbol
Plekhg4provided by RGD
Official Full Name
pleckstrin homology and RhoGEF domain containing G4provided by RGD
Primary source
RGD:1310790
See related
Ensembl:ENSRNOG00000016479 AllianceGenome:RGD:1310790
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310790
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in activation of GTPase activity. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 4. Orthologous to human PLEKHG4 (pleckstrin homology and RhoGEF domain containing G4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 17.7), Adrenal (RPKM 5.3) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50161722..50176491)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33251788..33266490)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37327395..37345047)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene formin homology 2 domain containing 1 Neighboring gene solute carrier family 9 member A5 Neighboring gene potassium channel tetramerization domain containing 19 Neighboring gene leucine rich repeat containing 36 Neighboring gene tubulin polymerization-promoting protein family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPases. Gupta M, et al. J Biol Chem, 2013 May 17. PMID 23572525, Free PMC Article
  2. Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle. Takenaka N, et al. Cell Signal, 2014 Nov. PMID 25025572
  3. Rho GTPases in insulin-stimulated glucose uptake. Satoh T. Small GTPases, 2014. PMID 24613967, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle
    Title: Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
puratrophin-1
Names
pleckstrin homology domain containing, family G (with RhoGef domain) member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    50161722..50176491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278642.1 → XP_063134712.1  puratrophin-1 isoform X4

  2. XM_063278644.1 → XP_063134714.1  puratrophin-1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZTC9

  3. XM_063278645.1 → XP_063134715.1  puratrophin-1 isoform X7

    UniProtKB/TrEMBL
    A6IYP6

  4. XM_039098213.2 → XP_038954141.1  puratrophin-1 isoform X4

    UniProtKB/TrEMBL
    D3ZQ60
    Conserved Domains (3) summary
    cd00160
    Location:705 → 871
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13242
    Location:871 → 1006
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    cl02488
    Location:419 → 570
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  5. XM_039098211.2 → XP_038954139.1  puratrophin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y027
    Conserved Domains (3) summary
    cd00160
    Location:749 → 915
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13242
    Location:915 → 1050
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    cl02488
    Location:463 → 614
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  6. XM_006255483.5 → XP_006255545.1  puratrophin-1 isoform X3

    See identical proteins and their annotated locations for XP_006255545.1

    UniProtKB/TrEMBL
    A0A8I5Y027
    Related
    ENSRNOP00000081851.1
    Conserved Domains (5) summary
    cd13242
    Location:891 → 1026
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    pfam00169
    Location:916 → 1018
    PH; PH domain
    pfam00621
    Location:728 → 899
    RhoGEF; RhoGEF domain
    cl02488
    Location:439 → 590
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl15787
    Location:189 → 313
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  7. XM_039098212.2 → XP_038954140.1  puratrophin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y027
    Related
    ENSRNOP00000087289.1
    Conserved Domains (3) summary
    cd00160
    Location:749 → 915
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13242
    Location:915 → 1050
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    cl02488
    Location:463 → 614
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  8. XM_063278643.1 → XP_063134713.1  puratrophin-1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AG98

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135870.1: Suppressed sequence

    Description
    NM_001135870.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from frog (X.tr): plekhg4 (GeneID:779571).
Nucleotide Protein Strain
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