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Ccsap centriole, cilia and spindle-associated protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 307926, updated on 3-Apr-2024

Summary

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Official Symbol
Ccsapprovided by RGD
Official Full Name
centriole, cilia and spindle-associated proteinprovided by RGD
Primary source
RGD:1563235
See related
Ensembl:ENSRNOG00000017690 AllianceGenome:RGD:1563235
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563235
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in mitotic spindle microtubule depolymerization and regulation of mitotic spindle assembly. Predicted to be located in centrosome; cilium; and mitotic spindle astral microtubule. Predicted to be active in axon; ciliary transition zone; and cytoskeleton. Orthologous to human CCSAP (centriole, cilia and spindle associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 88.5), Thymus (RPKM 39.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccsap in Genome Data Viewer
Location:
19q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68722417..68740908, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51824954..51843469, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56615326..56634031, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348963 Neighboring gene uncharacterized LOC134483403 Neighboring gene RAB4A, member RAS oncogene family Neighboring gene uncharacterized LOC108348965 Neighboring gene actin, alpha 1, skeletal muscle

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development. Backer CB, et al. Mol Biol Cell, 2012 Jun. PMID 22493317, Free PMC Article
  2. Polyglutamylated Tubulin Binding Protein C1orf96/CSAP Is Involved in Microtubule Stabilization in Mitotic Spindles. Ohta S, et al. PLoS One, 2015. PMID 26562023, Free PMC Article
  3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitotic spindle microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle astral microtubule ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centriole, cilia and spindle-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107441.1 → NP_001100911.1  centriole, cilia and spindle-associated protein

    See identical proteins and their annotated locations for NP_001100911.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474054
    UniProtKB/TrEMBL
    A6KIZ1, D3ZZM9
    Related
    ENSRNOP00000023911.4, ENSRNOT00000023911.8
    Conserved Domains (1) summary
    pfam15748
    Location:7 → 251
    CCSAP; Centriole, cilia and spindle-associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    68722417..68740908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255811.5 → XP_006255873.1  centriole, cilia and spindle-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006255873.1

    UniProtKB/TrEMBL
    A6KIZ1, D3ZZM9
    Conserved Domains (1) summary
    pfam15748
    Location:7 → 251
    CCSAP; Centriole, cilia and spindle-associated

  2. XM_063278071.1 → XP_063134141.1  centriole, cilia and spindle-associated protein isoform X1

    UniProtKB/TrEMBL
    A6KIZ1, D3ZZM9
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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