Trim67 tripartite motif-containing 67 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trim67provided by RGD
Official Full Name: tripartite motif-containing 67provided by RGD
Primary source: RGD:1560667
See related: Ensembl:ENSRNOG00000019024 AllianceGenome:RGD:1560667
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560667
Summary: Predicted to enable zinc ion binding activity. Predicted to act upstream of or within negative regulation of Ras protein signal transduction; positive regulation of neuron projection development; and positive regulation of ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Orthologous to human TRIM67 (tripartite motif containing 67). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 9.9), Adrenal (RPKM 7.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (69659857..69703290)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (52763991..52805906)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (57554665..57593401)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU026737 (e-PCR)
- UniSTS:113986

BF396236 (e-PCR)
- UniSTS:245708

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tripartite motif-containing protein 67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135715.1 → NP_001129187.1 tripartite motif-containing protein 67

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

D3ZTX1

Related

ENSRNOP00000032148.4, ENSRNOT00000032359.5

Conserved Domains (5) summary

smart00502
Location:336 → 462

BBC; B-Box C-terminal domain

cd00063
Location:515 → 591

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00643
Location:290 → 329

zf-B_box; B-box zinc finger

cd12889
Location:588 → 759

SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67

cl17238
Location:7 → 47

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

69659857..69703290

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017601304.3 → XP_017456793.1 tripartite motif-containing protein 67 isoform X3
XM_063278073.1 → XP_063134143.1 tripartite motif-containing protein 67 isoform X1
XM_063278074.1 → XP_063134144.1 tripartite motif-containing protein 67 isoform X2