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Kif13a kinesin family member 13A [ Rattus norvegicus (Norway rat) ]

Gene ID: 308173, updated on 19-May-2024

Summary

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Official Symbol
Kif13aprovided by RGD
Official Full Name
kinesin family member 13Aprovided by RGD
Primary source
RGD:1307825
See related
Ensembl:ENSRNOG00000001455 AllianceGenome:RGD:1307825
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including melanosome organization; plus-end-directed vesicle transport along microtubule; and protein transport. Predicted to be located in several cellular components, including centrosome; midbody; and trans-Golgi network membrane. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Orthologous to human KIF13A (kinesin family member 13A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 165.8), Muscle (RPKM 112.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kif13a in Genome Data Viewer
Location:
17p14
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (17972227..18154763)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (17766597..17948517)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (18151582..18335027)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor interacting Ras-like 1, pseudogene 1 Neighboring gene uncharacterized LOC108348531 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482696 Neighboring gene uncharacterized LOC134482695 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120097853 Neighboring gene ribosomal protein L27, pseudogene 4 Neighboring gene nucleoporin 153

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. Nakagawa T, et al. Cell, 2000 Nov 10. PMID 11106728
  2. AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis. Delevoye C, et al. J Cell Biol, 2009 Oct 19. PMID 19841138, Free PMC Article
  3. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Sagona AP, et al. Nat Cell Biol, 2010 Apr. PMID 20208530
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polarized transport requires AP-1-mediated recruitment of KIF13A and KIF13B at the trans-Golgi.
    Title: Polarized transport requires AP-1-mediated recruitment of KIF13A and KIF13B at the trans-Golgi.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in melanosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plus-end-directed vesicle transport along microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF13A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107462.1 → NP_001100932.1  kinesin-like protein KIF13A

    See identical proteins and their annotated locations for NP_001100932.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473977
    UniProtKB/TrEMBL
    A6J709, D3ZM20
    Related
    ENSRNOP00000060386.2, ENSRNOT00000066447.2
    Conserved Domains (6) summary
    smart00129
    Location:9 → 296
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:383 → 480
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl22853
    Location:3 → 296
    Motor_domain; Myosin and Kinesin motor domain
    pfam12423
    Location:685 → 729
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1148 → 1207
    DUF3694; Kinesin protein
    pfam16183
    Location:293 → 405
    Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    17972227..18154763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276527.1 → XP_063132597.1  kinesin-like protein KIF13A isoform X1

  2. XM_063276529.1 → XP_063132599.1  kinesin-like protein KIF13A isoform X3

  3. XM_063276531.1 → XP_063132601.1  kinesin-like protein KIF13A isoform X5

  4. XM_063276533.1 → XP_063132603.1  kinesin-like protein KIF13A isoform X7

  5. XM_063276528.1 → XP_063132598.1  kinesin-like protein KIF13A isoform X2

  6. XM_063276530.1 → XP_063132600.1  kinesin-like protein KIF13A isoform X4

  7. XM_063276536.1 → XP_063132606.1  kinesin-like protein KIF13A isoform X10

  8. XM_063276532.1 → XP_063132602.1  kinesin-like protein KIF13A isoform X6

  9. XM_063276535.1 → XP_063132605.1  kinesin-like protein KIF13A isoform X9

  10. XM_063276538.1 → XP_063132608.1  kinesin-like protein KIF13A isoform X12

  11. XM_063276534.1 → XP_063132604.1  kinesin-like protein KIF13A isoform X8

  12. XM_063276539.1 → XP_063132609.1  kinesin-like protein KIF13A isoform X13

  13. XM_063276537.1 → XP_063132607.1  kinesin-like protein KIF13A isoform X11

  14. XM_063276540.1 → XP_063132610.1  kinesin-like protein KIF13A isoform X14

Nucleotide Protein Strain
Heading Accession and Version

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