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U2af2 U2 small nuclear RNA auxiliary factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308335, updated on 13-Apr-2024

Summary

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Official Symbol
U2af2provided by RGD
Official Full Name
U2 small nuclear RNA auxiliary factor 2provided by RGD
Primary source
RGD:1310690
See related
Ensembl:ENSRNOG00000015914 AllianceGenome:RGD:1310690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable C2H2 zinc finger domain binding activity; RNA binding activity; and enzyme binding activity. Predicted to be involved in mRNA splicing, via spliceosome; negative regulation of protein ubiquitination; and regulation of RNA splicing. Predicted to be located in nucleus. Predicted to be part of U2-type prespliceosome; U2AF complex; and commitment complex. Predicted to be active in nuclear speck. Orthologous to human U2AF2 (U2 small nuclear RNA auxiliary factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 409.1), Spleen (RPKM 321.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See U2af2 in Genome Data Viewer
Location:
1q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (77789752..77807307, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (68760911..68779730, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72312260..72329828, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ret finger protein-like 4A Neighboring gene Epsin 1 Neighboring gene coiled-coil domain containing 106 Neighboring gene zinc finger protein 581-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor. Zamore PD, et al. Proc Natl Acad Sci U S A, 1989 Dec. PMID 2531895, Free PMC Article
  2. Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution. Zamore PD, et al. EMBO J, 1991 Jan. PMID 1824937, Free PMC Article
  3. The splicing factor U2AF65 stabilizes TRF1 protein by inhibiting its ubiquitin-dependent proteolysis. Kim J, et al. Biochem Biophys Res Commun, 2014 Jan 17. PMID 24389012
  4. WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes. Davies RC, et al. Genes Dev, 1998 Oct 15. PMID 9784496, Free PMC Article
  5. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Webby CJ, et al. Science, 2009 Jul 3. PMID 19574390

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables poly-pyrimidine tract binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pre-mRNA 3'-splice site binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pre-mRNA 3'-splice site binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Prp19 complex ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type prespliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2AF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2AF complex ISO
Inferred from Sequence Orthology
more info
  
part_of commitment complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
splicing factor U2AF 65 kDa subunit
Names
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427197.1 → NP_001414126.1  splicing factor U2AF 65 kDa subunit isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KNR7

  2. NM_001427198.1 → NP_001414127.1  splicing factor U2AF 65 kDa subunit isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    77789752..77807307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589964.3 → XP_017445453.1  splicing factor U2AF 65 kDa subunit isoform X2

    UniProtKB/TrEMBL
    A0A8I6A9Y1
    Conserved Domains (1) summary
    TIGR01642
    Location:4 → 455
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

  2. XM_017589963.3 → XP_017445452.1  splicing factor U2AF 65 kDa subunit isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9Y1
    Conserved Domains (1) summary
    TIGR01642
    Location:4 → 459
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

  3. XM_063288682.1 → XP_063144752.1  splicing factor U2AF 65 kDa subunit isoform X3

  4. XM_039100506.2 → XP_038956434.1  splicing factor U2AF 65 kDa subunit isoform X4

    Conserved Domains (1) summary
    TIGR01642
    Location:1 → 310
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
Nucleotide Protein Strain
Heading Accession and Version

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