U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ddx18 DEAD-box helicase 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308490, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Ddx18provided by RGD
Official Full Name
DEAD-box helicase 18provided by RGD
Primary source
RGD:1549712
See related
AllianceGenome:RGD:1549712
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MrDb
Summary
Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Involved in cellular response to estradiol stimulus. Predicted to be located in chromosome. Predicted to be active in nucleolus. Orthologous to human DDX18 (DEAD-box helicase 18). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Thymus (RPKM 162.4), Spleen (RPKM 130.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
13q11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (35282391..35296038, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (32729697..32743161, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (37522558..37536066, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 5B Neighboring gene uncharacterized LOC134481622 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 50 Neighboring gene uncharacterized LOC120096234

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. Grandori C, et al. EMBO J, 1996 Aug 15. PMID 8861962, Free PMC Article
  2. DExD/H-box RNA helicases in ribosome biogenesis. Martin R, et al. RNA Biol, 2013 Jan. PMID 22922795, Free PMC Article
  3. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. Sekiguchi T, et al. Nucleic Acids Res, 2006. PMID 16963496, Free PMC Article
  4. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Ohta S, et al. Cell, 2010 Sep 3. PMID 20813266, Free PMC Article
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC95311

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ATP-dependent RNA helicase DDX18
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
Myc-regulated DEAD box protein
NP_001006997.1
XP_063128478.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006996.1 → NP_001006997.1  ATP-dependent RNA helicase DDX18

    See identical proteins and their annotated locations for NP_001006997.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083919
    UniProtKB/TrEMBL
    A6K809, Q5XHY0
    Conserved Domains (4) summary
    smart00487
    Location:198 → 386
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:404 → 533
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:183 → 390
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam13959
    Location:565 → 623
    DUF4217; Domain of unknown function (DUF4217)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    35282391..35296038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272408.1 → XP_063128478.1  ATP-dependent RNA helicase DDX18 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous