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Nfkbid NFKB inhibitor delta [ Rattus norvegicus (Norway rat) ]

Gene ID: 308496, updated on 5-Mar-2024

Summary

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Official Symbol
Nfkbidprovided by RGD
Official Full Name
NFKB inhibitor deltaprovided by RGD
Primary source
RGD:1308055
See related
AllianceGenome:RGD:1308055
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ta-nfkbh; RGD1308055
Summary
Predicted to enable NF-kappaB binding activity. Predicted to be involved in T cell receptor signaling pathway; positive regulation of T-helper 17 cell differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; negative regulation of T cell differentiation in thymus; and positive regulation of thymocyte apoptotic process. Predicted to be active in nucleus. Orthologous to human NFKBID (NFKB inhibitor delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 19.1), Spleen (RPKM 19.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nfkbid in Genome Data Viewer
Location:
1q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94808459..94824726)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85679353..85690415)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88883816..88892543)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane immune signaling adaptor Tyrobp Neighboring gene hematopoietic cell signal transducer Neighboring gene amyloid beta precursor like protein 1 Neighboring gene kirre like nephrin family adhesion molecule 2 Neighboring gene NPHS1 adhesion molecule, nephrin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor. Fiorini E, et al. Mol Cell, 2002 Mar. PMID 11931770
  2. Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation. Jeltsch KM, et al. Nat Immunol, 2014 Nov. PMID 25282160
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T-helper 17 cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NF-kappa-B inhibitor delta
Names
T-cell activation NFKB-like protein
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    94808459..94824726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093862.2 → XP_038949790.1  NF-kappa-B inhibitor delta isoform X2

    UniProtKB/TrEMBL
    A6J9X3
    Conserved Domains (3) summary
    PHA03095
    Location:60 → 301
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:62 → 96
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:191 → 292
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_063277834.1 → XP_063133904.1  NF-kappa-B inhibitor delta isoform X1

RNA

  1. XR_010059974.1 RNA Sequence

  2. XR_010059969.1 RNA Sequence

  3. XR_010059970.1 RNA Sequence

  4. XR_010059971.1 RNA Sequence

  5. XR_010059972.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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