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Garre1 granule associated Rac and RHOG effector 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308509, updated on 13-Apr-2024

Summary

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Official Symbol
Garre1provided by RGD
Official Full Name
granule associated Rac and RHOG effector 1provided by RGD
Primary source
RGD:1308428
See related
Ensembl:ENSRNOG00000021129 AllianceGenome:RGD:1308428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308428
Summary
Predicted to enable CCR4-NOT complex binding activity and small GTPase binding activity. Predicted to be involved in Rac protein signal transduction. Predicted to be located in P-body. Orthologous to human GARRE1 (granule associated Rac and RHOG effector 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 149.4), Heart (RPKM 134.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Garre1 in Genome Data Viewer
Location:
1q21
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95999305..96077641, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86862121..86939725, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (90097331..90176119, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene programmed cell death 2-like Neighboring gene glucose-6-phosphate isomerase Neighboring gene ribosomal protein S23, pseudogene 12 Neighboring gene uncharacterized LOC120099790 Neighboring gene uncharacterized LOC120099791 Neighboring gene LSM14A mRNA processing body assembly factor Neighboring gene transfer RNA serine (anticodon AGA) 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Youn JY, et al. Mol Cell, 2018 Feb 1. PMID 29395067
  2. Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Bagci H, et al. Nat Cell Biol, 2020 Jan. PMID 31871319
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CCR4-NOT complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CCR4-NOT complex binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
granule associated Rac and RHOG effector protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271233.1 → NP_001258162.1  granule associated Rac and RHOG effector protein 1

    See identical proteins and their annotated locations for NP_001258162.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8J8XFB5, A6JA91
    Related
    ENSRNOP00000067998.1, ENSRNOT00000076987.3
    Conserved Domains (1) summary
    pfam15923
    Location:59 → 187
    DUF4745; Domain of unknown function (DUF4745)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    95999305..96077641 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261654.1 → XP_063117724.1  granule associated Rac and RHOG effector protein 1 isoform X2

  2. XM_008759155.4 → XP_008757377.1  granule associated Rac and RHOG effector protein 1 isoform X1

    See identical proteins and their annotated locations for XP_008757377.1

    UniProtKB/TrEMBL
    A0A8J8XFB5, A6JA91
    Conserved Domains (1) summary
    pfam15923
    Location:59 → 187
    DUF4745; Domain of unknown function (DUF4745)

  3. XM_006228850.5 → XP_006228912.1  granule associated Rac and RHOG effector protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006228912.1

    UniProtKB/TrEMBL
    A0A8J8XFB5, A6JA91
    Conserved Domains (1) summary
    pfam15923
    Location:59 → 187
    DUF4745; Domain of unknown function (DUF4745)

  4. XM_008759157.4 → XP_008757379.1  granule associated Rac and RHOG effector protein 1 isoform X1

    See identical proteins and their annotated locations for XP_008757379.1

    UniProtKB/TrEMBL
    A0A8J8XFB5, A6JA91
    Conserved Domains (1) summary
    pfam15923
    Location:59 → 187
    DUF4745; Domain of unknown function (DUF4745)

  5. XM_006228851.5 → XP_006228913.1  granule associated Rac and RHOG effector protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006228913.1

    UniProtKB/TrEMBL
    A0A8J8XFB5, A6JA91
    Conserved Domains (1) summary
    pfam15923
    Location:59 → 187
    DUF4745; Domain of unknown function (DUF4745)

  6. XM_063261655.1 → XP_063117725.1  granule associated Rac and RHOG effector protein 1 isoform X3

  7. XM_063261650.1 → XP_063117720.1  granule associated Rac and RHOG effector protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8J8XFB5

  8. XM_063261647.1 → XP_063117717.1  granule associated Rac and RHOG effector protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8J8XFB5

  9. XM_039111613.2 → XP_038967541.1  granule associated Rac and RHOG effector protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8J8XFB5, A6JA91
    Conserved Domains (1) summary
    pfam15923
    Location:59 → 187
    DUF4745; Domain of unknown function (DUF4745)

  10. XM_008759156.4 → XP_008757378.1  granule associated Rac and RHOG effector protein 1 isoform X1

    See identical proteins and their annotated locations for XP_008757378.1

    UniProtKB/TrEMBL
    A0A8J8XFB5, A6JA91
    Conserved Domains (1) summary
    pfam15923
    Location:59 → 187
    DUF4745; Domain of unknown function (DUF4745)

  11. XM_063261657.1 → XP_063117727.1  granule associated Rac and RHOG effector protein 1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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