U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tnrc6a trinucleotide repeat containing adaptor 6A [ Rattus norvegicus (Norway rat) ]

Gene ID: 308971, updated on 2-May-2024

Summary

Go to the top of the page Help
Official Symbol
Tnrc6aprovided by RGD
Official Full Name
trinucleotide repeat containing adaptor 6Aprovided by RGD
Primary source
RGD:1307268
See related
Ensembl:ENSRNOG00000024737 AllianceGenome:RGD:1307268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tnrc6
Summary
Predicted to enable nucleic acid binding activity. Predicted to be involved in miRNA mediated inhibition of translation and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within cellular response to starvation. Predicted to be located in Golgi apparatus. Predicted to be part of RISC complex. Predicted to be active in P-body and nucleoplasm. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 6. Orthologous to human TNRC6A (trinucleotide repeat containing adaptor 6A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 150.0), Lung (RPKM 137.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tnrc6a in Genome Data Viewer
Location:
1q36
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (186992457..187146764)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (177561898..177715669)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (192991584..193146403)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485175 Neighboring gene RB binding protein 6, ubiquitin ligase Neighboring gene uncharacterized LOC120099930 Neighboring gene RNA, U6 small nuclear 799 Neighboring gene uncharacterized LOC134483807 Neighboring gene solute carrier family 5 member 11

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Distinct temporal expression of the GW182 paralog TNRC6A in neurons regulates dendritic arborization. Nawalpuri B, et al. J Cell Sci, 2021 Aug 15. PMID 34328181
  2. Argonaute proteins at a glance. Ender C, et al. J Cell Sci, 2010 Jun 1. PMID 20484662
  3. Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Wakiyama M, et al. Genes Dev, 2007 Aug 1. PMID 17671087, Free PMC Article
  4. The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Huntzinger E, et al. Nucleic Acids Res, 2013 Jan. PMID 23172285, Free PMC Article
  5. GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. Yang Z, et al. J Cell Sci, 2004 Nov 1. PMID 15494374

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct temporal expression of the GW182 paralog TNRC6A in neurons regulates dendritic arborization.
    Title: Distinct temporal expression of the GW182 paralog TNRC6A in neurons regulates dendritic arborization.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in P-body assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endoderm development ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA-mediated gene silencing by inhibition of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA-mediated post-transcriptional gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
part_of RISC complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
trinucleotide repeat-containing gene 6A protein
Names
trinucleotide repeat containing 6
trinucleotide repeat containing 6a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395157.2 → NP_001382086.1  trinucleotide repeat-containing gene 6A protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6GAR2, F1M9Y8
    Related
    ENSRNOP00000083407.1, ENSRNOT00000096111.1
    Conserved Domains (5) summary
    pfam10427
    Location:1078 → 1203
    Ago_hook; Argonaute hook
    pfam12938
    Location:1298 → 1483
    M_domain; M domain of GW182
    pfam16608
    Location:1508 → 1769
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
    cd12711
    Location:1777 → 1868
    RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
    NF033849
    Location:604 → 863
    ser_rich_anae_1; serine-rich protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    186992457..187146764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759747.4 → XP_008757969.1  trinucleotide repeat-containing gene 6A protein isoform X1

    UniProtKB/TrEMBL
    F1M9Y8
    Conserved Domains (4) summary
    cd12711
    Location:1791 → 1873
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1081 → 1212
    Ago_hook; Argonaute hook
    pfam12938
    Location:1307 → 1492
    M_domain; M domain of GW182
    pfam16608
    Location:1515 → 1790
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  2. XM_017589208.3 → XP_017444697.1  trinucleotide repeat-containing gene 6A protein isoform X3

    UniProtKB/TrEMBL
    F1M9Y8

  3. XM_017589209.3 → XP_017444698.1  trinucleotide repeat-containing gene 6A protein isoform X6

    UniProtKB/TrEMBL
    A0A8I6ASC0
    Related
    ENSRNOP00000096367.1
    Conserved Domains (4) summary
    cd12711
    Location:1742 → 1824
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1081 → 1212
    Ago_hook; Argonaute hook
    pfam12938
    Location:1292 → 1443
    M_domain; M domain of GW182
    pfam16608
    Location:1466 → 1741
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  4. XM_063263201.1 → XP_063119271.1  trinucleotide repeat-containing gene 6A protein isoform X9

  5. XM_008759749.4 → XP_008757971.1  trinucleotide repeat-containing gene 6A protein isoform X2

    UniProtKB/TrEMBL
    F1M9Y8
    Related
    ENSRNOP00000071070.2
    Conserved Domains (4) summary
    cd12711
    Location:1780 → 1862
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1081 → 1201
    Ago_hook; Argonaute hook
    pfam12938
    Location:1296 → 1481
    M_domain; M domain of GW182
    pfam16608
    Location:1504 → 1779
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  6. XM_039078265.2 → XP_038934193.1  trinucleotide repeat-containing gene 6A protein isoform X7

    UniProtKB/TrEMBL
    F1M9Y8
    Related
    ENSRNOP00000017885.8
    Conserved Domains (5) summary
    pfam10427
    Location:1034 → 1159
    Ago_hook; Argonaute hook
    pfam12938
    Location:1254 → 1439
    M_domain; M domain of GW182
    pfam16608
    Location:1464 → 1725
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
    cd12711
    Location:1733 → 1824
    RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
    NF033849
    Location:560 → 819
    ser_rich_anae_1; serine-rich protein

  7. XM_063263199.1 → XP_063119269.1  trinucleotide repeat-containing gene 6A protein isoform X8

  8. XM_063263213.1 → XP_063119283.1  trinucleotide repeat-containing gene 6A protein isoform X10

  9. XM_063263192.1 → XP_063119262.1  trinucleotide repeat-containing gene 6A protein isoform X4

  10. XM_063263204.1 → XP_063119274.1  trinucleotide repeat-containing gene 6A protein isoform X10

  11. XM_063263194.1 → XP_063119264.1  trinucleotide repeat-containing gene 6A protein isoform X5

  12. XM_063263221.1 → XP_063119291.1  trinucleotide repeat-containing gene 6A protein isoform X10

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107549.2: Suppressed sequence

    Description
    NM_001107549.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous