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Rce1 Ras converting CAAX endopeptidase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309153, updated on 11-Apr-2024

Summary

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Official Symbol
Rce1provided by RGD
Official Full Name
Ras converting CAAX endopeptidase 1provided by RGD
Primary source
RGD:1309261
See related
Ensembl:ENSRNOG00000019468 AllianceGenome:RGD:1309261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable exopeptidase activity and metalloendopeptidase activity. Predicted to be involved in CAAX-box protein processing and protein prenylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human RCE1 (Ras converting CAAX endopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 104.9), Thymus (RPKM 93.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rce1 in Genome Data Viewer
Location:
1q43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211328769..211345944, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201899358..201902593, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219860826..219863933, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 5, pseudogene 10 Neighboring gene similar to human chromosome 11 open reading frame 86 Neighboring gene pyruvate carboxylase Neighboring gene leucine rich repeat and fibronectin type III domain containing 4 Neighboring gene TOP6B like initiator of meiotic double strand breaks Neighboring gene uncharacterized LOC102553046 Neighboring gene spectrin, beta, non-erythrocytic 2 Neighboring gene RNA binding motif protein 14 Neighboring gene RNA binding motif protein 4B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. Burrows JF, et al. J Biol Chem, 2009 Apr 3. PMID 19188362, Free PMC Article
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables exopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables exopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CAAX-box protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CAAX-box protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in CAAX-box protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in CAAX-box protein processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
CAAX prenyl protease 2
Names
FACE-2
RCE1 homolog, prenyl protein peptidase
RCE1 homolog, prenyl protein protease
farnesylated proteins-converting enzyme 2
prenyl protein-specific endoprotease 2
NP_001094055.1
XP_006230850.1
XP_006230852.1
XP_006230853.1
XP_008758357.1
XP_008758358.1
XP_038935311.1
XP_038935325.1
XP_038935329.1
XP_063120382.1
XP_063120392.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100585.1 → NP_001094055.1  CAAX prenyl protease 2

    See identical proteins and their annotated locations for NP_001094055.1

    Status: VALIDATED

    Source sequence(s)
    BC087629, BC158593
    UniProtKB/TrEMBL
    A6HYY1, Q5M955
    Conserved Domains (1) summary
    pfam02517
    Location:164 → 267
    Abi; CAAX protease self-immunity

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    211328769..211345944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264312.1 → XP_063120382.1  CAAX prenyl protease 2 isoform X7

  2. XM_039079383.2 → XP_038935311.1  CAAX prenyl protease 2 isoform X3

    Conserved Domains (1) summary
    pfam02517
    Location:136 → 213
    Abi; CAAX protease self-immunity

  3. XM_039079397.2 → XP_038935325.1  CAAX prenyl protease 2 isoform X6

  4. XM_006230791.5 → XP_006230853.1  CAAX prenyl protease 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I6ABC8
    Related
    ENSRNOP00000091297.1
    Conserved Domains (2) summary
    COG1266
    Location:169 → 245
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam02517
    Location:164 → 243
    Abi; CAAX protease self-immunity

  5. XM_006230790.5 → XP_006230852.1  CAAX prenyl protease 2 isoform X4

    See identical proteins and their annotated locations for XP_006230852.1

    UniProtKB/Swiss-Prot
    B0BMW8
    UniProtKB/TrEMBL
    A0A8L2QUF4
    Related
    ENSRNOP00000059208.2
    Conserved Domains (1) summary
    pfam02517
    Location:164 → 246
    Abi; CAAX protease self-immunity

  6. XM_006230788.5 → XP_006230850.1  CAAX prenyl protease 2 isoform X1

    Conserved Domains (1) summary
    pfam02517
    Location:164 → 241
    Abi; CAAX protease self-immunity

  7. XM_008760135.4 → XP_008758357.1  CAAX prenyl protease 2 isoform X2

    UniProtKB/TrEMBL
    G3V8J7
    Related
    ENSRNOP00000026454.4

  8. XM_063264322.1 → XP_063120392.1  CAAX prenyl protease 2 isoform X10

  9. XM_008760136.3 → XP_008758358.1  CAAX prenyl protease 2 isoform X9

    See identical proteins and their annotated locations for XP_008758358.1

    UniProtKB/TrEMBL
    A6HYY2
    Conserved Domains (2) summary
    COG1266
    Location:65 → 165
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam02517
    Location:60 → 163
    Abi; CAAX protease self-immunity

  10. XM_039079401.2 → XP_038935329.1  CAAX prenyl protease 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I6GIA5
    Related
    ENSRNOP00000090544.1
    Conserved Domains (1) summary
    pfam02517
    Location:60 → 137
    Abi; CAAX protease self-immunity

RNA

  1. XR_010053049.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0BMW8.1 GenPept UniProtKB/Swiss-Prot:B0BMW8

Gene LinkOut

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