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Batf2 basic leucine zipper ATF-like transcription factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309178, updated on 13-Apr-2024

Summary

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Official Symbol
Batf2provided by RGD
Official Full Name
basic leucine zipper ATF-like transcription factor 2provided by RGD
Primary source
RGD:1311481
See related
Ensembl:ENSRNOG00000021018 AllianceGenome:RGD:1311481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311481
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in defense response to protozoan; myeloid dendritic cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human BATF2 (basic leucine zipper ATF-like transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 17.3), Spleen (RPKM 13.1) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Batf2 in Genome Data Viewer
Location:
1q43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212897076..212905740)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203467291..203479428)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221538006..221546650)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097396 Neighboring gene sorting nexin 15 Neighboring gene uncharacterized LOC134483958 Neighboring gene ADP-ribosylation factor like GTPase 2 Neighboring gene membrane anchored junction protein Neighboring gene protein phosphatase 2, regulatory subunit B', beta Neighboring gene glycoprotein hormone subunit alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Compensatory dendritic cell development mediated by BATF-IRF interactions. Tussiwand R, et al. Nature, 2012 Oct 25. PMID 22992524, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in defense response to protozoan ISO
Inferred from Sequence Orthology
more info
  
involved_in myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
basic leucine zipper transcriptional factor ATF-like 2
Names
basic leucine zipper transcription factor, ATF-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400817.1 → NP_001387746.1  basic leucine zipper transcriptional factor ATF-like 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HZE9, D3ZT85
    Related
    ENSRNOP00000028527.4, ENSRNOT00000028527.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    212897076..212905740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094948.2 → XP_038950876.1  basic leucine zipper transcriptional factor ATF-like 2 isoform X2

    UniProtKB/TrEMBL
    A6HZF0
    Conserved Domains (2) summary
    cd14686
    Location:30 → 75
    bZIP; coiled coil [structural motif]
    cl21462
    Location:30 → 75
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  2. XM_039094962.2 → XP_038950890.1  basic leucine zipper transcriptional factor ATF-like 2 isoform X3

    UniProtKB/TrEMBL
    A6HZF0
    Conserved Domains (2) summary
    cd14686
    Location:28 → 73
    bZIP; coiled coil [structural motif]
    cl21462
    Location:28 → 73
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  3. XM_039094945.2 → XP_038950873.1  basic leucine zipper transcriptional factor ATF-like 2 isoform X1

    UniProtKB/TrEMBL
    A6HZF0
    Conserved Domains (2) summary
    cd14686
    Location:30 → 76
    bZIP; coiled coil [structural motif]
    cl21462
    Location:30 → 76
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  4. XM_006230953.5 → XP_006231015.1  basic leucine zipper transcriptional factor ATF-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006231015.1

    UniProtKB/TrEMBL
    A6HZF0
    Conserved Domains (2) summary
    cd14686
    Location:30 → 76
    bZIP; coiled coil [structural motif]
    cl21462
    Location:30 → 76
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version

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