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Lama2 laminin subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309368, updated on 2-May-2024

Summary

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Official Symbol
Lama2provided by RGD
Official Full Name
laminin subunit alpha 2provided by RGD
Primary source
RGD:1308889
See related
Ensembl:ENSRNOG00000011134 AllianceGenome:RGD:1308889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be an extracellular matrix structural constituent. Involved in Schwann cell differentiation. Located in basement membrane and dendritic spine. Biomarker of renovascular hypertension. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 674.5), Muscle (RPKM 322.3) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lama2 in Genome Data Viewer
Location:
1p12
Exon count:
67
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (19492126..20140056)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (17672675..18320641)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (18491264..19143486)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 4 Neighboring gene RuvB-like AAA ATPase 1, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene nucleophosmin 1, pseudogene 5 Neighboring gene uncharacterized LOC120098807 Neighboring gene U6 spliceosomal RNA Neighboring gene LSM5 homolog, U6 small nuclear RNA associated Neighboring gene Rho GTPase activating protein 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of the blood-testis barrier by a local axis in the testis: role of laminin α2 in the basement membrane. Gao Y, et al. FASEB J, 2017 Feb. PMID 27815338, Free PMC Article
  2. When do myopia genes have their effect? Comparison of genetic risks between children and adults. Tideman JW, et al. Genet Epidemiol, 2016 Dec. PMID 27611182
  3. Expression of dystroglycan complex in satellite cells of dorsal root ganglia. Masaki T, et al. Acta Neuropathol, 2001 Feb. PMID 11271373
  4. Expression of laminin alpha2 chain during normal and pathological growth of myocardium in rat and human. Oliviéro P, et al. Cardiovasc Res, 2000 May. PMID 10773239
  5. Expression of laminin-2 by normal and neoplastic rat C cells during the development of medullary thyroid carcinoma. Lekmine F, et al. Virchows Arch, 1999 Apr. PMID 10335943

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Laminin alpha2 in the basement membrane (BM) seems to play a crucial role in the blood-testis barrier-BM axis by modulating BTB dynamics during spermatogenesis.
    Title: Regulation of the blood-testis barrier by a local axis in the testis: role of laminin α2 in the basement membrane.
  2. Identification of cell adhesive sequences in the N-terminal region of the laminin alpha2 chain.
    Title: Identification of cell adhesive sequences in the N-terminal region of the laminin α2 chain.
  3. The binding of a small LG4-5 modules of laminin-211 to alpha-dystroglycan is important in preventing anoikis and that attachment plus binding is necessary for maximal cell survival.
    Title: LG4-5 domains of laminin-211 binds alpha-dystroglycan to allow myotube attachment and prevent anoikis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables extracellular matrix structural constituent IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Schwann cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of synaptic transmission, cholinergic ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic cleft ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
laminin subunit alpha-2
Names
laminin, alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427039.1 → NP_001413968.1  laminin subunit alpha-2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2JWX2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    19492126..20140056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264627.1 → XP_063120697.1  laminin subunit alpha-2 isoform X1

  2. XM_063264628.1 → XP_063120698.1  laminin subunit alpha-2 isoform X2

  3. XM_063264630.1 → XP_063120700.1  laminin subunit alpha-2 isoform X4

  4. XM_063264632.1 → XP_063120702.1  laminin subunit alpha-2 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZPP7

  5. XM_063264629.1 → XP_063120699.1  laminin subunit alpha-2 isoform X3

  6. XM_063264637.1 → XP_063120707.1  laminin subunit alpha-2 isoform X6

  7. XM_063264642.1 → XP_063120712.1  laminin subunit alpha-2 isoform X7

    UniProtKB/TrEMBL
    A6JPF2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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