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Gnl1 G protein nucleolar 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309593, updated on 5-Mar-2024

Summary

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Official Symbol
Gnl1provided by RGD
Official Full Name
G protein nucleolar 1provided by RGD
Primary source
RGD:1303051
See related
Ensembl:ENSRNOG00000000798 AllianceGenome:RGD:1303051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activity. Predicted to be involved in cellular response to DNA damage stimulus. Orthologous to human GNL1 (G protein nucleolar 1 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 152.5), Kidney (RPKM 114.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gnl1 in Genome Data Viewer
Location:
20p12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (2787939..2796924, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (2783130..2792115, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3290543..3299494, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483848 Neighboring gene RT1 class I, locus T24, gene 1 Neighboring gene uncharacterized LOC134483845 Neighboring gene proline rich 3 Neighboring gene ATP binding cassette subfamily F member 1 Neighboring gene microRNA 877

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Matsuoka S, et al. Science, 2007 May 25. PMID 17525332
  2. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212500.3 → NP_997665.1  guanine nucleotide-binding protein-like 1

    See identical proteins and their annotated locations for NP_997665.1

    Status: VALIDATED

    Source sequence(s)
    BC129081, BX883048
    UniProtKB/Swiss-Prot
    Q6MG06
    UniProtKB/TrEMBL
    A0A0G2K6Q5, A6KT59
    Related
    ENSRNOP00000073902.1, ENSRNOT00000090999.2
    Conserved Domains (2) summary
    cd01857
    Location:177 → 418
    HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
    PRK09563
    Location:179 → 516
    rbgA; GTPase YlqF; Reviewed

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    2787939..2796924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6MG06.1 GenPept UniProtKB/Swiss-Prot:Q6MG06

Gene LinkOut

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