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Vapa vesicle-associated membrane protein, associated protein A [ Mus musculus (house mouse) ]

Gene ID: 30960, updated on 5-Mar-2024

Summary

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Official Symbol
Vapaprovided by MGI
Official Full Name
vesicle-associated membrane protein, associated protein Aprovided by MGI
Primary source
MGI:MGI:1353561
See related
Ensembl:ENSMUSG00000024091 AllianceGenome:MGI:1353561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
33kDa; VAP-A; VAP33; VAMP-A; VAP-33
Summary
Predicted to enable several functions, including FFAT motif binding activity; identical protein binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including COPII-coated vesicle budding; modulation by host of viral genome replication; and protein localization to endoplasmic reticulum. Located in endoplasmic reticulum and microtubule cytoskeleton. Orthologous to human VAPA (VAMP associated protein A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 108.3), adrenal adult (RPKM 93.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Vapa in Genome Data Viewer
Location:
17 E1.1; 17 34.9 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (65887048..65925441, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65580053..65616462, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35400 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene thioredoxin domain containing 2 (spermatozoa) Neighboring gene predicted gene, 35477 Neighboring gene STARR-seq mESC enhancer starr_43016 Neighboring gene RAB31, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_43017 Neighboring gene STARR-seq mESC enhancer starr_43022

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. [Expression and function of VAP-33 in murine dendritic cell sarcoma]. Yang ZL, et al. Zhonghua Bing Li Xue Za Zhi, 2009 Aug. PMID 20021965
  2. Interaction between the motor protein prestin and the transporter protein VAPA. Sengupta S, et al. Biochim Biophys Acta, 2010 Jul. PMID 20359505, Free PMC Article
  3. Mouse VAP33 is associated with the endoplasmic reticulum and microtubules. Skehel PA, et al. Proc Natl Acad Sci U S A, 2000 Feb 1. PMID 10655491, Free PMC Article
  4. VAMP-associated protein-A regulates partitioning of oxysterol-binding protein-related protein-9 between the endoplasmic reticulum and Golgi apparatus. Wyles JP, et al. Exp Cell Res, 2004 Jul 15. PMID 15212954
  5. Neuronal ER-plasma membrane junctions organized by Kv2-VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis. Kirmiz M, et al. J Biol Chem, 2019 Nov 22. PMID 31594866, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CALCOCO1 acts with VAMP-associated proteins to mediate ER-phagy.
    Title: CALCOCO1 acts with VAMP-associated proteins to mediate ER-phagy.
  2. ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs.
    Title: ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs.
  3. the VAP-interacting membrane-associated phosphatidylinositol (PtdIns) transfer proteins PYK2 N-terminal domain-interacting receptor 2 (Nir2) and Nir3 specifically associate with Kv2.1 complexes.
    Title: Neuronal ER-plasma membrane junctions organized by Kv2-VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis.
  4. There was colocalization of Kv2.1 and Kv2.2 with endogenous VAPA at ER-PM junctions in mouse brain neurons. Expression of Kv2.1 recruits VAPA to ER-PM junctions. Knocking out VAPA expression disrupts Kv2.1 clustering.The domains of VAPs and Kv2.1 necessary and sufficient for their association at ER-PM junctions were identified.
    Title: Identification of VAPA and VAPB as Kv2 Channel-Interacting Proteins Defining Endoplasmic Reticulum-Plasma Membrane Junctions in Mammalian Brain Neurons.
  5. VAP-33 expression in dendritic cell sarcoma was related to vesicle transportation during antigen processing in dendritic cells.
    Title: [Expression and function of VAP-33 in murine dendritic cell sarcoma].
  6. These data suggest that VAPA could be involved in prestin's transportation inside outer hair cells (OHCs) and may facilitate the targeting of this abundant OHC protein to the plasma membrane.
    Title: Interaction between the motor protein prestin and the transporter protein VAPA.
  7. Vapa regulates partitioning of Osbp between the endoplasmic retiuculum and the Golgi apparatus.
    Title: VAMP-associated protein-A regulates partitioning of oxysterol-binding protein-related protein-9 between the endoplasmic reticulum and Golgi apparatus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FFAT motif binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FFAT motif binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle budding ISO
Inferred from Sequence Orthology
more info
  
involved_in ceramide transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum-plasma membrane tethering ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingomyelin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sterol transport ISO
Inferred from Sequence Orthology
more info
  
involved_in viral release from host cell ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vesicle-associated membrane protein-associated protein A
Names
33 kDa VAMP-associated protein
VAMP-associated protein A
synaptobrevin-associated protein of 33kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355402.1 → NP_001342331.1  vesicle-associated membrane protein-associated protein A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166058, CT030729
    UniProtKB/TrEMBL
    A0A3B2W837
    Related
    ENSMUSP00000156845.2, ENSMUST00000232686.2
    Conserved Domains (1) summary
    pfam00635
    Location:14 → 118
    Motile_Sperm; MSP (Major sperm protein) domain

  2. NM_013933.3 → NP_038961.2  vesicle-associated membrane protein-associated protein A isoform 2

    See identical proteins and their annotated locations for NP_038961.2

    Status: VALIDATED

    Source sequence(s)
    AK167381, BM899396
    Consensus CDS
    CCDS37677.1
    UniProtKB/Swiss-Prot
    Q3TJM1, Q9QY77, Q9WV55
    Related
    ENSMUSP00000024897.9, ENSMUST00000024897.10
    Conserved Domains (1) summary
    pfam00635
    Location:14 → 118
    Motile_Sperm; MSP (Major sperm protein) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    65887048..65925441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160637.1 → XP_036016530.1  vesicle-associated membrane protein-associated protein A isoform X2

    Conserved Domains (1) summary
    pfam00635
    Location:14 → 118
    Motile_Sperm; MSP (Major sperm protein) domain

  2. XM_017317500.3 → XP_017172989.1  vesicle-associated membrane protein-associated protein A isoform X1

    UniProtKB/TrEMBL
    A0A3B2W837
    Conserved Domains (1) summary
    pfam00635
    Location:14 → 118
    Motile_Sperm; MSP (Major sperm protein) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV55.2 GenPept UniProtKB/Swiss-Prot:Q9WV55

Gene LinkOut

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