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Vgll2 vestigial-like family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309772, updated on 5-Mar-2024

Summary

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Official Symbol
Vgll2provided by RGD
Official Full Name
vestigial-like family member 2provided by RGD
Primary source
RGD:1311903
See related
Ensembl:ENSRNOG00000000405 AllianceGenome:RGD:1311903
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein C-terminus binding activity and transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II and skeletal muscle tissue development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human VGLL2 (vestigial like family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 46.8) See more
Orthologs
human mouse all
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Genomic context

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See Vgll2 in Genome Data Viewer
Location:
20q11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (31952214..31958100)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (31409529..31415408)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (33077106..33082962)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC134483808 Neighboring gene heat shock protein family D (Hsp60) member 1, pseudogene 6 Neighboring gene uncharacterized LOC134483925 Neighboring gene transforming growth factor beta regulator 1-like Neighboring gene ROS proto-oncogene 1 , receptor tyrosine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation. Maeda T, et al. J Biol Chem, 2002 Dec 13. PMID 12376544
  2. A Sveinsson's chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ. Kitagawa M. Biochem Biophys Res Commun, 2007 Oct 5. PMID 17689488
  3. VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. Günther S, et al. Nucleic Acids Res, 2004. PMID 14762206, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription cofactor vestigial-like protein 2
Names
vestigial like 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107630.1 → NP_001101100.1  transcription cofactor vestigial-like protein 2

    See identical proteins and their annotated locations for NP_001101100.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474016
    UniProtKB/TrEMBL
    A6K475, D3ZG38
    Related
    ENSRNOP00000000456.3, ENSRNOT00000000456.5
    Conserved Domains (1) summary
    pfam07545
    Location:80 → 109
    Vg_Tdu; Vestigial/Tondu family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    31952214..31958100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256448.4 → XP_006256510.1  transcription cofactor vestigial-like protein 2 isoform X1

    Conserved Domains (1) summary
    pfam07545
    Location:79 → 109
    Vg_Tdu; Vestigial/Tondu family

  2. XM_008772885.3 → XP_008771107.1  transcription cofactor vestigial-like protein 2 isoform X2

    Conserved Domains (1) summary
    pfam07545
    Location:45 → 75
    Vg_Tdu; Vestigial/Tondu family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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