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Cmbl carboxymethylenebutenolidase homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 310201, updated on 3-Apr-2024

Summary

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Official Symbol
Cmblprovided by RGD
Official Full Name
carboxymethylenebutenolidase homologprovided by RGD
Primary source
RGD:1306952
See related
Ensembl:ENSRNOG00000011260 AllianceGenome:RGD:1306952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306952
Summary
Predicted to enable hydrolase activity. Predicted to be located in cytosol. Orthologous to human CMBL (carboxymethylenebutenolidase homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 460.9), Liver (RPKM 418.9) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cmbl in Genome Data Viewer
Location:
2q23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (84280128..84301878)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (82569257..82591007)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (84645084..84666836)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 6 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene uncharacterized LOC134485604 Neighboring gene chaperonin containing TCP1 subunit 5 Neighboring gene ATP synthase c subunit lysine N-methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC95111

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carboxymethylenebutenolidase homolog
Names
Ab2-225
carboxymethylenebutenolidase homolog (Pseudomonas)
liver regeneration-related protein LRRG072
NP_001008770.1
XP_006232159.1
XP_063137823.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008770.3 → NP_001008770.1  carboxymethylenebutenolidase homolog

    See identical proteins and their annotated locations for NP_001008770.1

    Status: VALIDATED

    Source sequence(s)
    BC088459, BF556107
    UniProtKB/Swiss-Prot
    Q7TP52
    UniProtKB/TrEMBL
    A6JMZ5
    Conserved Domains (1) summary
    COG0412
    Location:21 → 244
    DLH; Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    84280128..84301878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232097.5 → XP_006232159.1  carboxymethylenebutenolidase homolog isoform X2

    See identical proteins and their annotated locations for XP_006232159.1

    UniProtKB/Swiss-Prot
    Q7TP52
    UniProtKB/TrEMBL
    A6JMZ5
    Related
    ENSRNOP00000015448.4
    Conserved Domains (1) summary
    COG0412
    Location:21 → 244
    DLH; Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]

  2. XM_063281753.1 → XP_063137823.1  carboxymethylenebutenolidase homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZMF1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TP52.1 GenPept UniProtKB/Swiss-Prot:Q7TP52

Gene LinkOut

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