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Arsl arylsulfatase L [ Rattus norvegicus (Norway rat) ]

Gene ID: 310326, updated on 13-Apr-2024

Summary

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Official Symbol
Arslprovided by RGD
Official Full Name
arylsulfatase Lprovided by RGD
Primary source
RGD:1304917
See related
Ensembl:ENSRNOG00000028350 AllianceGenome:RGD:1304917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Arse
Summary
Predicted to enable arylsulfatase activity. Predicted to be located in Golgi apparatus. Human ortholog(s) of this gene implicated in X-linked chondrodysplasia punctata 1 and chondrodysplasia punctata. Orthologous to several human genes including ARSL (arylsulfatase L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 63.2), Lung (RPKM 60.3) and 9 other tissues See more
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Genomic context

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Location:
2q25
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (120966992..120975015)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (119038803..119047579)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (122876645..122884673)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase family, member 9 Neighboring gene surfeit 6, pseudogene 3 Neighboring gene zinc finger protein 267 Neighboring gene pyroglutamylated RFamide peptide receptor Neighboring gene POU class 5 homeobox 1, pseudogene 3 Neighboring gene annexin A5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. X-linked recessive chondrodysplasia punctata due to a new point mutation of the ARSE gene. Parenti G, et al. Am J Med Genet, 1997 Dec 12. PMID 9409863
  2. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Sardiello M, et al. Hum Mol Genet, 2005 Nov 1. PMID 16174644
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables arylsulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arylsulfatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arylsulfatase L
Names
arylsulfatase E (chondrodysplasia punctata 1)
NP_001041350.1
XP_006232343.1
XP_038958169.1
XP_038958170.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047885.2 → NP_001041350.1  arylsulfatase L precursor

    See identical proteins and their annotated locations for NP_001041350.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    F7FE18, Q32KK0
    Related
    ENSRNOP00000096386.1, ENSRNOT00000119901.1
    Conserved Domains (2) summary
    COG3119
    Location:31 → 541
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:34 → 531
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    120966992..120975015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102241.2 → XP_038958169.1  arylsulfatase L isoform X2

    Conserved Domains (1) summary
    cl23718
    Location:34 → 386
    ALP_like; alkaline phosphatases and sulfatases

  2. XM_039102242.2 → XP_038958170.1  arylsulfatase L isoform X3

    UniProtKB/TrEMBL
    B5DEF1
    Conserved Domains (1) summary
    cl23718
    Location:34 → 285
    ALP_like; alkaline phosphatases and sulfatases

  3. XM_006232281.4 → XP_006232343.1  arylsulfatase L isoform X1

    See identical proteins and their annotated locations for XP_006232343.1

    UniProtKB/TrEMBL
    F7FE18, Q32KK0
    Conserved Domains (2) summary
    COG3119
    Location:31 → 541
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:34 → 531
    ALP_like; alkaline phosphatases and sulfatases

RNA

  1. XR_005500286.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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