Ash1l ASH1 like histone lysine methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ash1lprovided by RGD
Official Full Name: ASH1 like histone lysine methyltransferaseprovided by RGD
Primary source: RGD:1306350
See related: Ensembl:ENSRNOG00000020386 AllianceGenome:RGD:1306350
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable histone methyltransferase activity (H3-K36 specific); histone methyltransferase activity (H3-K4 specific); and histone methyltransferase activity (H3-K9 specific). Predicted to be involved in histone H3-K36 dimethylation. Predicted to act upstream of or within several processes, including negative regulation of intracellular signal transduction; reproductive structure development; and tarsal gland development. Predicted to be located in Golgi apparatus and nucleoplasm. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 52. Orthologous to human ASH1L (ASH1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 262.8), Kidney (RPKM 262.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (176644393..176780848)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (174346267..174483057)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (188252592..188389251)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypoxia-sensitive cells trigger NK cell activation via the KLF4-ASH1L-ICAM-1 axis, contributing to impairment in the rat epididymis.
Title: Hypoxia-sensitive cells trigger NK cell activation via the KLF4-ASH1L-ICAM-1 axis, contributing to impairment in the rat epididymis.
Data show that Ash1l and EZH2 methyltransferases protein expression was significantly elevated in fibrotic liver and decreased in mutant matrix metalloproteinase-9 (mMMP-9) and human hepatocyte growth factor (hHGF) gene transfer treated fibrotic livers.
Title: Mutant MMP-9 and HGF gene transfer enhance resolution of CCl4-induced liver fibrosis in rats: role of ASH1 and EZH2 methyltransferases repression.

Submit: New GeneRIF Correction

General gene information

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Markers

D2Rat228 (e-PCR), detects polymorphism
- UniSTS:227379

RH137680 (e-PCR)
- UniSTS:219767

BF398837 (e-PCR)
- UniSTS:246950

AL033792 (e-PCR)
- UniSTS:93644

RH69490 (e-PCR)
- UniSTS:18661

BF398987 (e-PCR)
- UniSTS:247028

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables histone H3K36 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K4 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K4 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K9 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within decidualization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sebaceous gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within single fertilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tarsal gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within uterine gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within uterus morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase ASH1L

Names: ash1 (absent, small, or homeotic)-like; probable histone-lysine N-methyltransferase ASH1L

NP_001101159.1

EC 2.1.1.354

XP_008759376.1

EC 2.1.1.354

XP_008759377.1

EC 2.1.1.354

XP_008759380.1

EC 2.1.1.354

XP_008759381.1

EC 2.1.1.354

XP_038958241.1

EC 2.1.1.354

XP_038958243.2

EC 2.1.1.354

XP_063137913.1

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107689.2 → NP_001101159.1 histone-lysine N-methyltransferase ASH1L

See identical proteins and their annotated locations for NP_001101159.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A0G2K2W6, A6J6B3, D3ZKH4

Related

ENSRNOP00000072404.1, ENSRNOT00000085690.2

Conserved Domains (5) summary

cd05525
Location:2392 → 2497

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:2042 → 2093

AWS; associated with SET domains

smart00317
Location:2096 → 2216

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd04717
Location:2614 → 2748

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2535 → 2577

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

176644393..176780848

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761159.4 → XP_008759381.1 histone-lysine N-methyltransferase ASH1L isoform X2

See identical proteins and their annotated locations for XP_008759381.1

UniProtKB/TrEMBL

D3ZKH4

Conserved Domains (5) summary

cd05525
Location:2432 → 2537

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:2082 → 2133

AWS; associated with SET domains

cd04717
Location:2654 → 2788

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2575 → 2617

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L

cd19174
Location:2136 → 2276

SET_ASH1L; SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins
XM_008761158.3 → XP_008759380.1 histone-lysine N-methyltransferase ASH1L isoform X2

See identical proteins and their annotated locations for XP_008759380.1

UniProtKB/TrEMBL

D3ZKH4

Conserved Domains (5) summary

cd05525
Location:2432 → 2537

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:2082 → 2133

AWS; associated with SET domains

cd04717
Location:2654 → 2788

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2575 → 2617

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L

cd19174
Location:2136 → 2276

SET_ASH1L; SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins
XM_039102313.2 → XP_038958241.1 histone-lysine N-methyltransferase ASH1L isoform X2

UniProtKB/TrEMBL

D3ZKH4

Conserved Domains (5) summary

cd05525
Location:2432 → 2537

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:2082 → 2133

AWS; associated with SET domains

cd04717
Location:2654 → 2788

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2575 → 2617

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L

cd19174
Location:2136 → 2276

SET_ASH1L; SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins
XM_008761155.4 → XP_008759377.1 histone-lysine N-methyltransferase ASH1L isoform X2

See identical proteins and their annotated locations for XP_008759377.1

UniProtKB/TrEMBL

D3ZKH4

Related

ENSRNOP00000086010.1

Conserved Domains (5) summary

cd05525
Location:2432 → 2537

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:2082 → 2133

AWS; associated with SET domains

cd04717
Location:2654 → 2788

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2575 → 2617

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L

cd19174
Location:2136 → 2276

SET_ASH1L; SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins
XM_008761154.4 → XP_008759376.1 histone-lysine N-methyltransferase ASH1L isoform X2

See identical proteins and their annotated locations for XP_008759376.1

UniProtKB/TrEMBL

D3ZKH4

Conserved Domains (5) summary

cd05525
Location:2432 → 2537

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:2082 → 2133

AWS; associated with SET domains

cd04717
Location:2654 → 2788

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2575 → 2617

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L

cd19174
Location:2136 → 2276

SET_ASH1L; SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins
XM_039102315.2 → XP_038958243.2 histone-lysine N-methyltransferase ASH1L isoform X3
XM_063281843.1 → XP_063137913.1 histone-lysine N-methyltransferase ASH1L isoform X1

UniProtKB/TrEMBL

A0A8I6A1E5