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Otud7b OTU deubiquitinase 7B [ Rattus norvegicus (Norway rat) ]

Gene ID: 310677, updated on 3-Apr-2024

Summary

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Official Symbol
Otud7bprovided by RGD
Official Full Name
OTU deubiquitinase 7Bprovided by RGD
Primary source
RGD:1308111
See related
Ensembl:ENSRNOG00000042068 AllianceGenome:RGD:1308111
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308111
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; Lys48-specific deubiquitinase activity; and thiol-dependent deubiquitinase. Predicted to be involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of macromolecule metabolic process; and protein deubiquitination. Predicted to act upstream of or within in utero embryonic development and protein deubiquitination. Predicted to be active in cytoplasm and nucleus. Orthologous to human OTUD7B (OTU deubiquitinase 7B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 94.1), Heart (RPKM 90.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Otud7b in Genome Data Viewer
Location:
2q34
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186350811..186411461)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183661955..183722584)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198231353..198302220)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene uncharacterized LOC134485652 Neighboring gene uncharacterized LOC134485654 Neighboring gene developmental pluripotency-associated 4, pseudogene 7 Neighboring gene myotubularin related protein 11 Neighboring gene splicing factor 3B subunit 4 Neighboring gene synaptic vesicle glycoprotein 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. OTUD7B (Cezanne) ameliorates fibrosis after myocardial infarction via FAK-ERK/P38 MAPK signaling pathway. Zhang J, et al. Arch Biochem Biophys, 2022 Jul 30. PMID 35523269
  2. Transcranial direct-current stimulation protects against cerebral ischemia-reperfusion injury through regulating Cezanne-dependent signaling. Cheng J, et al. Exp Neurol, 2021 Nov. PMID 34324860
  3. Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination. Luong le A, et al. Circ Res, 2013 Jun 7. PMID 23564640, Free PMC Article
  4. A novel type of deubiquitinating enzyme. Evans PC, et al. J Biol Chem, 2003 Jun 20. PMID 12682062
  5. Isolation and characterization of two novel A20-like proteins. Evans PC, et al. Biochem J, 2001 Aug 1. PMID 11463333, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Kruppel-Like Factor 4.
    Title: Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel-Like Factor 4.
  2. OTUD7B (Cezanne) ameliorates fibrosis after myocardial infarction via FAK-ERK/P38 MAPK signaling pathway.
    Title: OTUD7B (Cezanne) ameliorates fibrosis after myocardial infarction via FAK-ERK/P38 MAPK signaling pathway.
  3. Transcranial direct-current stimulation protects against cerebral ischemia-reperfusion injury through regulating Cezanne-dependent signaling.
    Title: Transcranial direct-current stimulation protects against cerebral ischemia-reperfusion injury through regulating Cezanne-dependent signaling.
  4. Inflammatory responses to ischemia are controlled by a balance between ubiquitination and deubiquitination, and Cezanne is a key regulator of this process.
    Title: Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in mucosal immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
OTU domain-containing protein 7B
Names
OTU domain containing 7B
cellular zinc finger anti-NF-kappaB Cezanne
NP_001101167.1
XP_006233019.1
XP_063137950.1
XP_063137951.1
XP_063137952.1
XP_063137953.1
XP_063137954.1
XP_063137955.1
XP_063137956.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107697.1 → NP_001101167.1  OTU domain-containing protein 7B

    See identical proteins and their annotated locations for NP_001101167.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474015
    UniProtKB/TrEMBL
    A0A0G2K5N0, A6K349
    Related
    ENSRNOP00000073488.2, ENSRNOT00000078288.2
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:799 → 821
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    186350811..186411461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281883.1 → XP_063137953.1  OTU domain-containing protein 7B isoform X1

    UniProtKB/TrEMBL
    A6K349

  2. XM_063281885.1 → XP_063137955.1  OTU domain-containing protein 7B isoform X1

    UniProtKB/TrEMBL
    A6K349

  3. XM_063281880.1 → XP_063137950.1  OTU domain-containing protein 7B isoform X1

    UniProtKB/TrEMBL
    A6K349

  4. XM_006232957.5 → XP_006233019.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_006233019.1

    UniProtKB/TrEMBL
    A0A0G2K5N0, A6K349
    Conserved Domains (3) summary
    cd14347
    Location:4 → 46
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:799 → 821
    zf-A20; A20-like zinc finger
    cl19932
    Location:189 → 359
    OTU; OTU-like cysteine protease

  5. XM_063281882.1 → XP_063137952.1  OTU domain-containing protein 7B isoform X1

    UniProtKB/TrEMBL
    A6K349

  6. XM_063281881.1 → XP_063137951.1  OTU domain-containing protein 7B isoform X1

    UniProtKB/TrEMBL
    A6K349

  7. XM_063281886.1 → XP_063137956.1  OTU domain-containing protein 7B isoform X3

  8. XM_063281884.1 → XP_063137954.1  OTU domain-containing protein 7B isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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