U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Polr3c RNA polymerase III subunit C [ Rattus norvegicus (Norway rat) ]

Gene ID: 310685, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Polr3cprovided by RGD
Official Full Name
RNA polymerase III subunit Cprovided by RGD
Primary source
RGD:1311545
See related
Ensembl:ENSRNOG00000033560 AllianceGenome:RGD:1311545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex. Orthologous to human POLR3C (RNA polymerase III subunit C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 66.3), Spleen (RPKM 61.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2q34
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186935038..186950962, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (184246201..184262150, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198836282..198852368, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100888 Neighboring gene protein inhibitor of activated STAT, 3 Neighboring gene nudix hydrolase 17 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene ring finger protein 115 Neighboring gene CD160 molecule Neighboring gene PDZ domain containing 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation. Lefèvre S, et al. Nat Struct Mol Biol, 2011 Mar. PMID 21358628
  2. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Ablasser A, et al. Nat Immunol, 2009 Oct. PMID 19609254, Free PMC Article
  3. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, et al. Cell Cycle, 2010 Sep 15. PMID 20890107, Free PMC Article
  4. Gene duplication and neofunctionalization: POLR3G and POLR3GL. Renaud M, et al. Genome Res, 2014 Jan. PMID 24107381, Free PMC Article
  5. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. Hu P, et al. Mol Cell Biol, 2002 Nov. PMID 12391170, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DNA-directed RNA polymerase III subunit RPC3
Names
DNA-directed RNA polymerase III subunit C
RNA polymerase III subunit C3
polymerase (RNA) III (DNA directed) polypeptide C
polymerase (RNA) III subunit C

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012081.2 → NP_001012081.1  DNA-directed RNA polymerase III subunit RPC3

    See identical proteins and their annotated locations for NP_001012081.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q5XIL3
    UniProtKB/TrEMBL
    A0A8I5ZYW9, A6K394
    Related
    ENSRNOP00000085283.1, ENSRNOT00000100231.1
    Conserved Domains (2) summary
    pfam05645
    Location:146 → 344
    RNA_pol_Rpc82; RNA polymerase III subunit RPC82
    pfam08221
    Location:7 → 65
    HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain

  2. NM_001415056.1 → NP_001401985.1  DNA-directed RNA polymerase III subunit RPC3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q5XIL3
    UniProtKB/TrEMBL
    A6K394

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    186935038..186950962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281889.1 → XP_063137959.1  DNA-directed RNA polymerase III subunit RPC3 isoform X3

  2. XM_039102384.1 → XP_038958312.1  DNA-directed RNA polymerase III subunit RPC3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYW9, A0A8L2QFS6
    Related
    ENSRNOP00000028815.4, ENSRNOT00000028815.6
    Conserved Domains (2) summary
    pfam05645
    Location:157 → 355
    RNA_pol_Rpc82; RNA polymerase III subunit RPC82
    pfam08221
    Location:18 → 79
    HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain

  3. XM_063281888.1 → XP_063137958.1  DNA-directed RNA polymerase III subunit RPC3 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIL3.1 GenPept UniProtKB/Swiss-Prot:Q5XIL3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous