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Plppr5 phospholipid phosphatase related 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310812, updated on 5-Mar-2024

Summary

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Official Symbol
Plppr5provided by RGD
Official Full Name
phospholipid phosphatase related 5provided by RGD
Primary source
RGD:1309567
See related
Ensembl:ENSRNOG00000016878 AllianceGenome:RGD:1309567
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lppr5; PRG-5; Pap2d; RGD1309567
Summary
Predicted to enable lipid phosphatase activity and phosphatidate phosphatase activity. Predicted to be involved in several processes, including phospholipid dephosphorylation; phospholipid metabolic process; and positive regulation of cell projection organization. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human PLPPR5 (phospholipid phosphatase related 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 74.6), Testes (RPKM 17.5) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plppr5 in Genome Data Viewer
Location:
2q42
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (208143058..208422836)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (205525466..205737892)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219895141..220102333, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548639 Neighboring gene palmdelphin Neighboring gene phospholipid phosphatase related 4 Neighboring gene uncharacterized LOC134485953 Neighboring gene sorting nexin 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Plasticity-related gene 5 (PRG5) induces filopodia and neurite growth and impedes lysophosphatidic acid- and nogo-A-mediated axonal retraction. Broggini T, et al. Mol Biol Cell, 2010 Feb 15. PMID 20032306, Free PMC Article
  2. Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. Savaskan NE, et al. Eur J Neurosci, 2004 Jan. PMID 14750979
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phospholipid phosphatase-related protein type 5
Names
lipid phosphate phosphatase-related protein type 5
phosphatidic acid phosphatase type 2
phosphatidic acid phosphatase type 2d
plasticity-related protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107720.1 → NP_001101190.1  phospholipid phosphatase-related protein type 5

    See identical proteins and their annotated locations for NP_001101190.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473952
    UniProtKB/TrEMBL
    A0A8I6B5V9, A6HVB8, B3VQM3, F7EXV2
    Related
    ENSRNOP00000022905.5, ENSRNOT00000022905.6
    Conserved Domains (1) summary
    cd03384
    Location:118 → 267
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    208143058..208422836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281942.1 → XP_063138012.1  phospholipid phosphatase-related protein type 5 isoform X1

  2. XM_008761462.4 → XP_008759684.2  phospholipid phosphatase-related protein type 5 isoform X3

    UniProtKB/TrEMBL
    A0A8I6B5V9
    Conserved Domains (1) summary
    cd03384
    Location:125 → 274
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

  3. XM_039102433.2 → XP_038958361.1  phospholipid phosphatase-related protein type 5 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZQK9, A0A8I6B5V9
    Related
    ENSRNOP00000080680.1
    Conserved Domains (1) summary
    cd03384
    Location:125 → 274
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

  4. XM_063281943.1 → XP_063138013.1  phospholipid phosphatase-related protein type 5 isoform X5

  5. XM_039102432.2 → XP_038958360.1  phospholipid phosphatase-related protein type 5 isoform X2

    UniProtKB/TrEMBL
    A0A8I6B5V9
    Conserved Domains (1) summary
    cd03384
    Location:118 → 267
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
Nucleotide Protein Strain
Heading Accession and Version

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