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Tet2 tet methylcytosine dioxygenase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310859, updated on 13-Apr-2024

Summary

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Official Symbol
Tet2provided by RGD
Official Full Name
tet methylcytosine dioxygenase 2provided by RGD
Primary source
RGD:1311625
See related
Ensembl:ENSRNOG00000023579 AllianceGenome:RGD:1311625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311625
Summary
Predicted to enable ferrous iron binding activity; methylcytosine dioxygenase activity; and zinc ion binding activity. Involved in response to organic cyclic compound. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 155.2), Muscle (RPKM 114.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tet2 in Genome Data Viewer
Location:
2q43
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (224662654..224746819, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (221988645..222072813, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (238719389..238802975, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546359 Neighboring gene inorganic pyrophosphatase 2 Neighboring gene GC-rich promoter binding protein 1-like 2 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein L10 like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TET2 suppresses nasopharyngeal carcinoma progression by inhibiting glycolysis metabolism. Zhang X, et al. Cancer Cell Int, 2020. PMID 32774157, Free PMC Article
  2. Association of molecular characteristics with survival in advanced non-small cell lung cancer patients treated with checkpoint inhibitors. Zhao D, et al. Lung Cancer, 2020 Aug. PMID 32554069, Free PMC Article
  3. Expression Patterns for TETs, LGR5 and BMI1 in Cancer Stem-like Cells Isolated from Human Colon Cancer. Atlasy N, et al. Avicenna J Med Biotechnol, 2019 Apr-Jun. PMID 31057717, Free PMC Article
  4. DNA methylation of immune checkpoints in the peripheral blood of breast and colorectal cancer patients. Elashi AA, et al. Oncoimmunology, 2019. PMID 30713804, Free PMC Article
  5. Global DNA 5-Hydroxymethylcytosine and 5-Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma. Liu J, et al. Hepatology, 2019 Jan. PMID 30070373

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C-MYC ameliorates ventricular remodeling of myocardial infarction rats via binding to the promoter of microRNA-29a-3p to facilitate TET2 expression.
    Title: C-MYC ameliorates ventricular remodeling of myocardial infarction rats via binding to the promoter of microRNA-29a-3p to facilitate TET2 expression.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5-methylcytosine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5-methylcytosine dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within 5-methylcytosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA demethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA demethylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cytosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hemoglobin metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within liver morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in myeloid cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myeloid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression via chromosomal CpG island demethylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression via chromosomal CpG island demethylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within spleen development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
methylcytosine dioxygenase TET2
Names
probable methylcytosine dioxygenase TET2
tet oncogene family member 2
NP_001414486.1
XP_006233409.1
XP_008759756.1
XP_063138035.1
XP_063138036.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427557.1 → NP_001414486.1  methylcytosine dioxygenase TET2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    D4AC33

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    224662654..224746819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761534.4 → XP_008759756.1  methylcytosine dioxygenase TET2 isoform X2

    See identical proteins and their annotated locations for XP_008759756.1

    Conserved Domains (1) summary
    pfam12851
    Location:1255 → 1387
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily

  2. XM_006233347.5 → XP_006233409.1  methylcytosine dioxygenase TET2 isoform X1

    See identical proteins and their annotated locations for XP_006233409.1

    Conserved Domains (1) summary
    cl40427
    Location:1107 → 1439
    Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins

  3. XM_063281965.1 → XP_063138035.1  methylcytosine dioxygenase TET2 isoform X3

  4. XM_063281966.1 → XP_063138036.1  methylcytosine dioxygenase TET2 isoform X4

RNA

  1. XR_010063616.1 RNA Sequence

  2. XR_010063615.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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