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Dusp19 dual specificity phosphatase 19 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311151, updated on 11-Apr-2024

Summary

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Official Symbol
Dusp19provided by RGD
Official Full Name
dual specificity phosphatase 19provided by RGD
Primary source
RGD:1307457
See related
AllianceGenome:RGD:1307457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including phosphoprotein phosphatase activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in negative regulation of JUN kinase activity; positive regulation of JNK cascade; and positive regulation of JUN kinase activity. Predicted to act upstream of or within JNK cascade; negative regulation of MAPK cascade; and protein dephosphorylation. Predicted to be active in cytoplasm. Orthologous to human DUSP19 (dual specificity phosphatase 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 55.6), Lung (RPKM 40.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (85945289..86081289)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (65538424..65554465)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (67849966..67862475)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486397 Neighboring gene NCK-associated protein 1 Neighboring gene small nucleolar RNA U3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene nucleoporin 35 Neighboring gene torsin 1A interacting protein 2 like 1 Neighboring gene uncharacterized LOC120101446

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DUSP19 regulates IL-1β-induced apoptosis and MMPs expression in rat chondrocytes through JAK2/STAT3 signaling pathway. Yao ZZ, et al. Biomed Pharmacother, 2017 Dec. PMID 29174854
  2. DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis. Wang Y, et al. Mol Biosyst, 2016 Mar. PMID 26751999
  3. A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway. Zama T, et al. J Biol Chem, 2002 Jun 28. PMID 11959861
  4. Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. Zama T, et al. J Biol Chem, 2002 Jun 28. PMID 11959862
  5. A growing family of dual specificity phosphatases with low molecular masses. Aoki N, et al. J Biochem, 2001 Jul. PMID 11432789

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DSP19 up-regulation inhibited IL-1beta-induced chondrocytes apoptosis and MMPs expression through inactivating JAK2/STAT3 pathway.
    Title: DUSP19 regulates IL-1β-induced apoptosis and MMPs expression in rat chondrocytes through JAK2/STAT3 signaling pathway.
  2. the activity of JNK stimulated by leptin was suppressed by DUSP19 overexpression.
    Title: DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables JUN kinase phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables JUN kinase phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables MAP-kinase scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 19
NP_001101209.2
XP_038960797.1
XP_063139714.1
XP_063139715.1
XP_063139716.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107739.2 → NP_001101209.2  dual specificity protein phosphatase 19

    See identical proteins and their annotated locations for NP_001101209.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HMN2
    Conserved Domains (1) summary
    cd00127
    Location:64 → 199
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    85945289..86081289
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104869.2 → XP_038960797.1  dual specificity protein phosphatase 19 isoform X4

    Conserved Domains (1) summary
    cl28904
    Location:64 → 105
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_063283645.1 → XP_063139715.1  dual specificity protein phosphatase 19 isoform X2

  3. XM_063283646.1 → XP_063139716.1  dual specificity protein phosphatase 19 isoform X3

  4. XM_063283644.1 → XP_063139714.1  dual specificity protein phosphatase 19 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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