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Adar Adenosine deaminase acting on RNA [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31130, updated on 10-May-2024

Summary

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Official Symbol
Adarprovided by FlyBase
Official Full Name
Adenosine deaminase acting on RNAprovided by FlyBase
Primary source
FLYBASE:FBgn0026086
Locus tag
Dmel_CG12598
See related
AllianceGenome:FB:FBgn0026086
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
adar; ADAR; ADAR1; adr; cg12598; CG12598; dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1; hypnos-2
Summary
Enables double-stranded RNA adenosine deaminase activity. Involved in several processes, including RNA modification; locomotor rhythm; and male courtship behavior. Located in nucleolus. Is expressed in several structures, including amnioproctodeal invagination; central nervous system; embryonic/larval digestive system; germ band; and mesoderm anlage. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human ADARB1 (adenosine deaminase RNA specific B1) and ADARB2 (adenosine deaminase RNA specific B2 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Adar in Genome Data Viewer
Location:
2B9-2B9; 1-0.2 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1773725..1788065)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1667758..1682098)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sarcoglycan delta Neighboring gene prage Neighboring gene mir-981 stem loop Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuronal role of taxi is imperative for flight in Drosophila melanogaster. Varte V, et al. Gene, 2022 Jul 30. PMID 35597528
  2. Identification of RNA-binding protein targets with HyperTRIBE. Rahman R, et al. Nat Protoc, 2018 Aug. PMID 30013039, Free PMC Article
  3. The landscape of miRNA editing in animals and its impact on miRNA biogenesis and targeting. Li L, et al. Genome Res, 2018 Jan. PMID 29233923, Free PMC Article
  4. Dynamic hyper-editing underlies temperature adaptation in Drosophila. Buchumenski I, et al. PLoS Genet, 2017 Jul. PMID 28746393, Free PMC Article
  5. Evolutionary analysis reveals regulatory and functional landscape of coding and non-coding RNA editing. Zhang R, et al. PLoS Genet, 2017 Feb. PMID 28166241, Free PMC Article

See all (130) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene.
    Title: Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene.
  2. Proteome-Wide Analysis of ADAR-Mediated Messenger RNA Editing during Fruit Fly Ontogeny.
    Title: Proteome-Wide Analysis of ADAR-Mediated Messenger RNA Editing during Fruit Fly Ontogeny.
  3. Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons.
    Title: Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons.
  4. Drosophila Adar, despite being the homolog of mammalian ADAR2, also has functions similar to mammalian ADAR1.
    Title: Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila.
  5. our data shows that ADAR is essential for proper temperature adaptation, a key behavior trait that is essential for survival of flies in the wild. Moreover, our results suggest a more general role of ADAR in regulating RNA secondary structures in vivo
    Title: Dynamic hyper-editing underlies temperature adaptation in Drosophila.
  6. Deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dysfunction in glutamatergic neurons.
    Title: ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity.
  7. The study demonstrates that neuronal excitability is linked to dADAR expression levels in individual neurons.
    Title: The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster.
  8. loss of Adar increases quantal size, reduces the number of quanta of neurotransmitter released and perturbs the calcium dependence of synaptic release
    Title: Adar is essential for optimal presynaptic function.
  9. results demonstrate a novel role for dADAR protein in rnp-4f 5'-UTR alternative intron splicing regulation which is consistent with a previously proposed model.
    Title: An RNA electrophoretic mobility shift and mutational analysis of rnp-4f 5'-UTR intron splicing regulatory proteins in Drosophila reveals a novel new role for a dADAR protein isoform.
  10. Data suggeset that RNA editing enzyme ADAR-mediated editing is more widespread than previously indicated and largely occurs cotranscriptionally.
    Title: Nascent-seq indicates widespread cotranscriptional RNA editing in Drosophila.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA adenosine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA adenosine deaminase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-specific adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in adenosine to inosine editing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenosine to inosine editing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenosine to inosine editing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adult behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
adenosine deaminase acting on RNA
Names
Adar-PA
Adar-PB
Adar-PC
Adar-PD
Adar-PE
Adar-PF
Adar-PH
Adar-PI
Adar-PJ
Adar-PK
Adar-PM
Adar-PN
Adar-PO
Adar-PP
Adar-PQ
CG12598-PA
CG12598-PB
CG12598-PC
CG12598-PD
CG12598-PE
CG12598-PF
CG12598-PH
CG12598-PI
CG12598-PJ
CG12598-PK
CG12598-PM
CG12598-PN
CG12598-PO
CG12598-PP
CG12598-PQ
adenosine deaminase acting on rna
adenosine deaminases acting on RNA
hypnos-2
hypoxia, anoxia, sensitive 2
NP_001033821.1
NP_001245469.1
NP_001245470.1
NP_001245471.1
NP_001245472.2
NP_001245473.1
NP_001245474.1
NP_001245475.1
NP_001245476.1
NP_001245477.1
NP_001284791.1
NP_001284792.1
NP_001368969.1
NP_569940.2
NP_726761.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1773725..1788065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258548.2 → NP_001245477.1  adenosine deaminase acting on RNA, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245477.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
    UniProtKB/TrEMBL
    M9NGI0
    Conserved Domains (2) summary
    smart00358
    Location:34 → 96
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:236 → 607
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

  2. NM_001297862.1 → NP_001284791.1  adenosine deaminase acting on RNA, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284791.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
    UniProtKB/TrEMBL
    X2JHZ2
    Conserved Domains (3) summary
    smart00358
    Location:55 → 117
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:294 → 665
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    TIGR04238
    Location:57 → 242
    seadorna_dsRNA; seadornavirus double-stranded RNA-binding protein

  3. NM_166903.3 → NP_726761.2  adenosine deaminase acting on RNA, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726761.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
    Related
    FBpp0070287
    Conserved Domains (2) summary
    smart00358
    Location:51 → 113
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:253 → 624
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

  4. NM_001258547.2 → NP_001245476.1  adenosine deaminase acting on RNA, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245476.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
    UniProtKB/TrEMBL
    M9NEQ7
    Conserved Domains (2) summary
    smart00358
    Location:57 → 119
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:259 → 630
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

  5. NM_001038732.3 → NP_001033821.1  adenosine deaminase acting on RNA, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033821.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2PE36
    Conserved Domains (1) summary
    smart00358
    Location:55 → 117
    DSRM; Double-stranded RNA binding motif

  6. NM_130584.4 → NP_569940.2  adenosine deaminase acting on RNA, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569940.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
    UniProtKB/TrEMBL
    M9NFQ6
    Related
    FBpp0070286
    Conserved Domains (2) summary
    smart00358
    Location:55 → 117
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:257 → 628
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

  7. NM_001258545.2 → NP_001245474.1  adenosine deaminase acting on RNA, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245474.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
    UniProtKB/TrEMBL
    M9NFQ8
    Conserved Domains (3) summary
    smart00358
    Location:51 → 113
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:290 → 661
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    TIGR04238
    Location:53 → 238
    seadorna_dsRNA; seadornavirus double-stranded RNA-binding protein

  8. NM_001258546.2 → NP_001245475.1  adenosine deaminase acting on RNA, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245475.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6K8G4, C6SUW1
    Conserved Domains (2) summary
    smart00358
    Location:55 → 117
    DSRM; Double-stranded RNA binding motif
    cl02661
    Location:294 → 388
    A_deamin; Adenosine-deaminase (editase) domain

  9. NM_001258542.2 → NP_001245471.1  adenosine deaminase acting on RNA, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245471.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6K8G4, C6SUW1
    Conserved Domains (2) summary
    smart00358
    Location:55 → 117
    DSRM; Double-stranded RNA binding motif
    cl02661
    Location:294 → 388
    A_deamin; Adenosine-deaminase (editase) domain

  10. NM_001258544.2 → NP_001245473.1  adenosine deaminase acting on RNA, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245473.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDJ0
    Conserved Domains (1) summary
    smart00358
    Location:57 → 119
    DSRM; Double-stranded RNA binding motif

  11. NM_001258543.2 → NP_001245472.2  adenosine deaminase acting on RNA, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245472.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6K8G3, C6SUW1, M9NGH5
    Conserved Domains (2) summary
    smart00358
    Location:55 → 117
    DSRM; Double-stranded RNA binding motif
    cl02661
    Location:257 → 351
    A_deamin; Adenosine-deaminase (editase) domain

  12. NM_001297863.1 → NP_001284792.1  adenosine deaminase acting on RNA, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284792.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SUW1, X2JDG6
    Conserved Domains (2) summary
    smart00358
    Location:34 → 96
    DSRM; Double-stranded RNA binding motif
    cl02661
    Location:236 → 330
    A_deamin; Adenosine-deaminase (editase) domain

  13. NM_001258541.2 → NP_001245470.1  adenosine deaminase acting on RNA, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245470.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SUW1, M9NE37
    Conserved Domains (2) summary
    smart00358
    Location:52 → 114
    DSRM; Double-stranded RNA binding motif
    cl02661
    Location:291 → 385
    A_deamin; Adenosine-deaminase (editase) domain

  14. NM_001258540.1 → NP_001245469.1  adenosine deaminase acting on RNA, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245469.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
    UniProtKB/TrEMBL
    M9NFQ6
    Conserved Domains (2) summary
    smart00358
    Location:55 → 117
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:257 → 628
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

  15. NM_001382020.1 → NP_001368969.1  adenosine deaminase acting on RNA, isoform Q [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96834, Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII1, Q9NII2, Q9W562
    UniProtKB/TrEMBL
    A0A6H2EFI6
    Conserved Domains (3) summary
    smart00552
    Location:306 → 677
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19865
    Location:105 → 167
    DSRM_STRBP_RED-like_rpt1; first double-stranded RNA binding motif of STRBP, ILF3, RED1, RED2 and similar proteins
    cl00054
    Location:213 → 259
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A6H2EFI6 A0A6H2EFI6
C6K8G3 C6K8G3
C6K8G4 C6K8G4
M9NDJ0 M9NDJ0
M9NE37 M9NE37
M9NEQ7 M9NEQ7
M9NFQ6 M9NFQ6
M9NFQ8 M9NFQ8
M9NGI0 M9NGI0
Q2PE36 Q2PE36
Q9NII1.2 Q9NII1
X2JDG6 X2JDG6
X2JHZ2 X2JHZ2

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