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Mtfr1 mitochondrial fission regulator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311403, updated on 13-Apr-2024

Summary

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Official Symbol
Mtfr1provided by RGD
Official Full Name
mitochondrial fission regulator 1provided by RGD
Primary source
RGD:1304936
See related
Ensembl:ENSRNOG00000021359 AllianceGenome:RGD:1304936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304936
Summary
Predicted to be involved in aerobic respiration and mitochondrial fission. Predicted to be located in cytosol and plasma membrane. Predicted to be active in mitochondrion. Orthologous to human MTFR1 (mitochondrial fission regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 105.6), Testes (RPKM 93.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtfr1 in Genome Data Viewer
Location:
2q24
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (103594458..103629697)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (101678331..101713547)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (104005696..104040914)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100569 Neighboring gene armadillo repeat containing 1 Neighboring gene phosphodiesterase 7A Neighboring gene RAB5C, member RAS oncogene family, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of the LncRNA Gpr19 attenuates ischemia-reperfusion injury after acute myocardial infarction by inhibiting apoptosis and oxidative stress via the miR-324-5p/Mtfr1 axis. Huang L, et al. IUBMB Life, 2020 Mar. PMID 31622017
  2. The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration. Monticone M, et al. J Cell Physiol, 2010 Nov. PMID 20568109
  3. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of the LncRNA Gpr19 attenuates ischemia-reperfusion injury after acute myocardial infarction by inhibiting apoptosis and oxidative stress via the miR-324-5p/Mtfr1 axis.
    Title: Inhibition of the LncRNA Gpr19 attenuates ischemia-reperfusion injury after acute myocardial infarction by inhibiting apoptosis and oxidative stress via the miR-324-5p/Mtfr1 axis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aerobic respiration IEA
Inferred from Electronic Annotation
more info
  
involved_in aerobic respiration ISO
Inferred from Sequence Orthology
more info
  
involved_in aerobic respiration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial fission regulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100977.2 → NP_001094447.2  mitochondrial fission regulator 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    A3F823, G3V9A7
    UniProtKB/TrEMBL
    A0A8I6A026
    Related
    ENSRNOP00000040894.3, ENSRNOT00000045586.4
    Conserved Domains (1) summary
    pfam05308
    Location:24 → 253
    Mito_fiss_reg; Mitochondrial fission regulator

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    103594458..103629697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232179.5 → XP_006232241.1  mitochondrial fission regulator 1 isoform X1

    See identical proteins and their annotated locations for XP_006232241.1

    UniProtKB/Swiss-Prot
    A3F823, G3V9A7
    UniProtKB/TrEMBL
    A0A8I6A026
    Conserved Domains (1) summary
    pfam05308
    Location:24 → 253
    Mito_fiss_reg; Mitochondrial fission regulator

  2. XM_063281996.1 → XP_063138066.1  mitochondrial fission regulator 1 isoform X1

    UniProtKB/Swiss-Prot
    A3F823, G3V9A7

  3. XM_063281993.1 → XP_063138063.1  mitochondrial fission regulator 1 isoform X1

    UniProtKB/Swiss-Prot
    A3F823, G3V9A7

  4. XM_063281997.1 → XP_063138067.1  mitochondrial fission regulator 1 isoform X1

    UniProtKB/Swiss-Prot
    A3F823, G3V9A7

  5. XM_063281994.1 → XP_063138064.1  mitochondrial fission regulator 1 isoform X1

    UniProtKB/Swiss-Prot
    A3F823, G3V9A7

  6. XM_063281995.1 → XP_063138065.1  mitochondrial fission regulator 1 isoform X1

    UniProtKB/Swiss-Prot
    A3F823, G3V9A7

  7. XM_063281998.1 → XP_063138068.1  mitochondrial fission regulator 1 isoform X1

    UniProtKB/Swiss-Prot
    A3F823, G3V9A7

  8. XM_006232180.5 → XP_006232242.1  mitochondrial fission regulator 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A026, A0A8I6A6A8
    Related
    ENSRNOP00000086488.1
    Conserved Domains (1) summary
    pfam05308
    Location:5 → 234
    Mito_fiss_reg; Mitochondrial fission regulator

  9. XM_063281992.1 → XP_063138062.1  mitochondrial fission regulator 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3V9A7.1 GenPept UniProtKB/Swiss-Prot:G3V9A7

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