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Ap4e1 adaptor related protein complex 4 subunit epsilon 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311404, updated on 13-Apr-2024

Summary

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Official Symbol
Ap4e1provided by RGD
Official Full Name
adaptor related protein complex 4 subunit epsilon 1provided by RGD
Primary source
RGD:1562199
See related
Ensembl:ENSRNOG00000022938 AllianceGenome:RGD:1562199
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562199
Summary
Predicted to enable cargo adaptor activity. Predicted to be involved in receptor-mediated endocytosis. Predicted to be located in Golgi apparatus. Predicted to be part of AP-4 adaptor complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 51 and stuttering. Orthologous to human AP4E1 (adaptor related protein complex 4 subunit epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 72.7), Kidney (RPKM 65.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q36
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (134726338..134792820)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (114272997..114339484)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (119484714..119548491)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 7 Neighboring gene signal peptide peptidase-like 2A Neighboring gene uncharacterized LOC134486145 Neighboring gene mitochondrial fission regulator 1-like Neighboring gene uncharacterized LOC134486146 Neighboring gene biliverdin reductase A Neighboring gene non-SMC condensin I complex, subunit H

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AP-4, a novel protein complex related to clathrin adaptors. Dell'Angelica EC, et al. J Biol Chem, 1999 Mar 12. PMID 10066790
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cargo adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-4 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-4 adaptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AP-4 complex subunit epsilon-1
Names
adaptor-related protein complex 4, epsilon 1 subunit
adaptor-related protein complex AP-4, epsilon 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191742.1 → NP_001178671.1  AP-4 complex subunit epsilon-1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    D3ZX21
    Related
    ENSRNOP00000037349.5, ENSRNOT00000037390.7
    Conserved Domains (2) summary
    pfam01602
    Location:51 → 595
    Adaptin_N; Adaptin N terminal region
    pfam14807
    Location:1026 → 1125
    AP4E_app_platf; Adaptin AP4 complex epsilon appendage platform

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    134726338..134792820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283751.1 → XP_063139821.1  AP-4 complex subunit epsilon-1 isoform X1

  2. XM_039104990.2 → XP_038960918.1  AP-4 complex subunit epsilon-1 isoform X2

    Conserved Domains (2) summary
    pfam01602
    Location:2 → 205
    Adaptin_N; Adaptin N terminal region
    pfam14807
    Location:639 → 739
    AP4E_app_platf; Adaptin AP4 complex epsilon appendage platform

  3. XM_063283752.1 → XP_063139822.1  AP-4 complex subunit epsilon-1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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