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Polr3f RNA polymerase III subunit F [ Rattus norvegicus (Norway rat) ]

Gene ID: 311487, updated on 11-Apr-2024

Summary

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Official Symbol
Polr3fprovided by RGD
Official Full Name
RNA polymerase III subunit Fprovided by RGD
Primary source
RGD:1306428
See related
Ensembl:ENSRNOG00000007548 AllianceGenome:RGD:1306428
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable double-stranded DNA binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to be part of RNA polymerase III complex. Orthologous to human POLR3F (RNA polymerase III subunit F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 69.3), Brain (RPKM 68.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Polr3f in Genome Data Viewer
Location:
3q41
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (152361798..152378169)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (131908466..131924838)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (138684685..138701055)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 133 Neighboring gene double zinc ribbon and ankyrin repeat domains 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene RB binding protein 9, serine hydrolase Neighboring gene Sec23 homolog B, COPII coat complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation. Lefèvre S, et al. Nat Struct Mol Biol, 2011 Mar. PMID 21358628
  2. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Chiu YH, et al. Cell, 2009 Aug 7. PMID 19631370, Free PMC Article
  3. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, et al. Cell Cycle, 2010 Sep 15. PMID 20890107, Free PMC Article
  4. Gene duplication and neofunctionalization: POLR3G and POLR3GL. Renaud M, et al. Genome Res, 2014 Jan. PMID 24107381, Free PMC Article
  5. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. Hu P, et al. Mol Cell Biol, 2002 Nov. PMID 12391170, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase III subunit RPC6
Names
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
polymerase (RNA) III subunit F
NP_001101254.1
XP_038960973.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107784.1 → NP_001101254.1  DNA-directed RNA polymerase III subunit RPC6

    See identical proteins and their annotated locations for NP_001101254.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474026
    UniProtKB/TrEMBL
    A0A8I6G3H2, A6K758, D3ZQ56
    Related
    ENSRNOP00000010468.4, ENSRNOT00000010468.6
    Conserved Domains (1) summary
    pfam05158
    Location:67 → 370
    RNA_pol_Rpc34; RNA polymerase Rpc34 subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    152361798..152378169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105045.2 → XP_038960973.1  DNA-directed RNA polymerase III subunit RPC6 isoform X1

    Conserved Domains (1) summary
    pfam05158
    Location:1 → 231
    RNA_pol_Rpc34; RNA polymerase Rpc34 subunit
Nucleotide Protein Strain
Heading Accession and Version

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