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Pofut1 protein O-fucosyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311551, updated on 4-Apr-2024

Summary

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Official Symbol
Pofut1provided by RGD
Official Full Name
protein O-fucosyltransferase 1provided by RGD
Primary source
RGD:1303001
See related
Ensembl:ENSRNOG00000010104 AllianceGenome:RGD:1303001
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fut12; O-FucT-1
Summary
Predicted to enable peptide-O-fucosyltransferase activity. Predicted to be involved in protein O-linked fucosylation and regulation of Notch signaling pathway. Predicted to act upstream of or within several processes, including Notch signaling pathway; circulatory system development; and somitogenesis. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Dowling-Degos disease. Orthologous to human POFUT1 (protein O-fucosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 115.8), Kidney (RPKM 113.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pofut1 in Genome Data Viewer
Location:
3q41
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (162168855..162195798)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141708618..141735558)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148722864..148749743)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene testis specific protein, Y-linked 26 Neighboring gene PLAG1 like zinc finger 2 Neighboring gene ribosomal protein L27A like 6 Neighboring gene kinesin family member 3B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Glycosylation regulates Notch signalling. Haines N, et al. Nat Rev Mol Cell Biol, 2003 Oct. PMID 14570055
  2. O-fucosylation of notch occurs in the endoplasmic reticulum. Luo Y, et al. J Biol Chem, 2005 Mar 25. PMID 15653671
  3. Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains. Wang Y, et al. Glycobiology, 1996 Dec. PMID 9023546
  4. Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations. McMillan BJ, et al. Glycobiology, 2017 Aug 1. PMID 28334865, Free PMC Article
  5. Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. Wang Y, et al. J Biol Chem, 2001 Oct 26. PMID 11524432

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables fucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide-O-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-O-fucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in fucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked fucosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within somitogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
GDP-fucose protein O-fucosyltransferase 1
Names
peptide-O-fucosyltransferase 1
NP_001002278.1
XP_017447268.1
XP_038960997.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002278.3 → NP_001002278.1  GDP-fucose protein O-fucosyltransferase 1 precursor

    See identical proteins and their annotated locations for NP_001002278.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q6EV70
    UniProtKB/TrEMBL
    A6KHU6
    Related
    ENSRNOP00000013730.1, ENSRNOT00000013730.4
    Conserved Domains (1) summary
    cd11302
    Location:37 → 386
    O-FucT-1; GDP-fucose protein O-fucosyltransferase 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    162168855..162195798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591779.3 → XP_017447268.1  GDP-fucose protein O-fucosyltransferase 1 isoform X1

  2. XM_039105069.2 → XP_038960997.1  GDP-fucose protein O-fucosyltransferase 1 isoform X2

    Conserved Domains (1) summary
    cd11302
    Location:1 → 271
    O-FucT-1; GDP-fucose protein O-fucosyltransferase 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6EV70.1 GenPept UniProtKB/Swiss-Prot:Q6EV70

Gene LinkOut

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