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Fam83d family with sequence similarity 83, member D [ Rattus norvegicus (Norway rat) ]

Gene ID: 311598, updated on 5-Mar-2024

Summary

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Official Symbol
Fam83dprovided by RGD
Official Full Name
family with sequence similarity 83, member Dprovided by RGD
Primary source
RGD:1565583
See related
Ensembl:ENSRNOG00000015794 AllianceGenome:RGD:1565583
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565583
Summary
Predicted to enable kinesin binding activity; microtubule binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of cell cycle G1/S phase transition; protein localization to mitotic spindle; and regulation of intracellular signal transduction. Predicted to be located in cytoplasm; intercellular bridge; and mitotic spindle. Predicted to be active in cytosol and mitotic spindle pole. Orthologous to human FAM83D (family with sequence similarity 83 member D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 37.1), Thymus (RPKM 32.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q42
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (167841748..167861062)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (147421941..147441211)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (155269344..155288612)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene actin related protein 5 Neighboring gene protein phosphatase 1, regulatory subunit 16B Neighboring gene 60S ribosomal protein L13-like Neighboring gene DEAH-box helicase 35 Neighboring gene uncharacterized LOC134486305

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FAM83D activates the MEK/ERK signaling pathway and promotes cell proliferation in hepatocellular carcinoma. Wang D, et al. Biochem Biophys Res Commun, 2015 Mar 6. PMID 25646692
  2. FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7. Wang Z, et al. Oncotarget, 2013 Dec. PMID 24344117, Free PMC Article
  3. The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle. Santamaria A, et al. Curr Biol, 2008 May 20. PMID 18485706
  4. Proteome analysis of the human mitotic spindle. Sauer G, et al. Mol Cell Proteomics, 2005 Jan. PMID 15561729
  5. Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer. Cipriano R, et al. Mol Cancer Res, 2014 Aug. PMID 24736947, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell cycle G1/S phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein FAM83D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107796.1 → NP_001101266.1  protein FAM83D

    See identical proteins and their annotated locations for NP_001101266.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474005
    UniProtKB/TrEMBL
    A6JWX9, D4ABG0
    Related
    ENSRNOP00000021308.2, ENSRNOT00000021308.5
    Conserved Domains (2) summary
    pfam13091
    Location:149 → 284
    PLDc_2; PLD-like domain
    cl15239
    Location:21 → 291
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    167841748..167861062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283852.1 → XP_063139922.1  protein FAM83D isoform X3

  2. XM_039105094.2 → XP_038961022.1  protein FAM83D isoform X2

    Conserved Domains (1) summary
    cl15239
    Location:1 → 128
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

  3. XM_039105095.2 → XP_038961023.1  protein FAM83D isoform X2

    Conserved Domains (1) summary
    cl15239
    Location:1 → 128
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

  4. XM_039105093.1 → XP_038961021.1  protein FAM83D isoform X1

    Conserved Domains (1) summary
    cl15239
    Location:2 → 134
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
Nucleotide Protein Strain
Heading Accession and Version

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