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Slc35c2 solute carrier family 35 member C2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311637, updated on 3-Apr-2024

Summary

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Official Symbol
Slc35c2provided by RGD
Official Full Name
solute carrier family 35 member C2provided by RGD
Primary source
RGD:1311250
See related
Ensembl:ENSRNOG00000018649 AllianceGenome:RGD:1311250
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable antiporter activity. Predicted to be involved in UDP-glucose transmembrane transport. Predicted to act upstream of or within negative regulation of gene expression; positive regulation of Notch signaling pathway; and protein O-linked fucosylation. Located in cis-Golgi network and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human SLC35C2 (solute carrier family 35 member C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 44.5), Kidney (RPKM 42.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc35c2 in Genome Data Viewer
Location:
3q42
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (174431688..174442852, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (154012262..154023549, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161801194..161812318, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486205 Neighboring gene uncharacterized LOC134486204 Neighboring gene engulfment and cell motility 2 Neighboring gene zinc finger protein 663 Neighboring gene zinc finger protein 334

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells. Lu L, et al. J Biol Chem, 2010 Nov 12. PMID 20837470, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in UDP-glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fucosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein O-linked fucosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 35 member C2
Names
solute carrier family 35 (GDP-fucose transporter), member C2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107803.1 → NP_001101273.1  solute carrier family 35 member C2

    See identical proteins and their annotated locations for NP_001101273.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474005
    UniProtKB/TrEMBL
    A0A0G2K491, B2RYM9, F7ELK2
    Conserved Domains (1) summary
    pfam03151
    Location:16 → 313
    TPT; Triose-phosphate Transporter family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    174431688..174442852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283880.1 → XP_063139950.1  solute carrier family 35 member C2 isoform X3

  2. XM_063283872.1 → XP_063139942.1  solute carrier family 35 member C2 isoform X1

  3. XM_063283876.1 → XP_063139946.1  solute carrier family 35 member C2 isoform X1

  4. XM_006235588.5 → XP_006235650.1  solute carrier family 35 member C2 isoform X2

    See identical proteins and their annotated locations for XP_006235650.1

    UniProtKB/TrEMBL
    A0A0G2K491, B2RYM9, F7ELK2
    Related
    ENSRNOP00000025238.4
    Conserved Domains (1) summary
    pfam03151
    Location:16 → 313
    TPT; Triose-phosphate Transporter family

  5. XM_063283878.1 → XP_063139948.1  solute carrier family 35 member C2 isoform X2

    UniProtKB/TrEMBL
    B2RYM9, F7ELK2

  6. XM_063283873.1 → XP_063139943.1  solute carrier family 35 member C2 isoform X1

  7. XM_008762504.4 → XP_008760726.1  solute carrier family 35 member C2 isoform X2

    See identical proteins and their annotated locations for XP_008760726.1

    UniProtKB/TrEMBL
    A0A0G2K491, B2RYM9, F7ELK2
    Conserved Domains (1) summary
    pfam03151
    Location:16 → 313
    TPT; Triose-phosphate Transporter family

  8. XM_063283879.1 → XP_063139949.1  solute carrier family 35 member C2 isoform X2

    UniProtKB/TrEMBL
    B2RYM9, F7ELK2

  9. XM_063283874.1 → XP_063139944.1  solute carrier family 35 member C2 isoform X1

  10. XM_063283877.1 → XP_063139947.1  solute carrier family 35 member C2 isoform X2

    UniProtKB/TrEMBL
    B2RYM9, F7ELK2

  11. XM_063283875.1 → XP_063139945.1  solute carrier family 35 member C2 isoform X1

  12. XM_017591795.3 → XP_017447284.1  solute carrier family 35 member C2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K491, B2RYM9, F7ELK2
Nucleotide Protein Strain
Heading Accession and Version

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