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Zfp512b zinc finger protein 512B [ Rattus norvegicus (Norway rat) ]

Gene ID: 311721, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp512bprovided by RGD
Official Full Name
zinc finger protein 512Bprovided by RGD
Primary source
RGD:1305284
See related
Ensembl:ENSRNOG00000015558 AllianceGenome:RGD:1305284
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Urkl1; Znf512b
Summary
Predicted to enable kinase activity. Predicted to be involved in phosphorylation. Predicted to be located in nucleoplasm. Orthologous to human ZNF512B (zinc finger protein 512B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 71.9), Kidney (RPKM 67.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q43
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (189065036..189075587, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168687520..168698067, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (177078708..177089210, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548047 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 Neighboring gene uridine-cytidine kinase 1-like 1 Neighboring gene sterile alpha motif domain containing 10 Neighboring gene pre-mRNA processing factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Key role of uridine kinase and uridine phosphorylase in the homeostatic regulation of purine and pyrimidine salvage in brain. Balestri F, et al. Neurochem Int, 2007 Dec. PMID 17643556
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 512B
Names
uridine kinase-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107809.1 → NP_001101279.1  zinc finger protein 512B

    See identical proteins and their annotated locations for NP_001101279.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474066
    UniProtKB/TrEMBL
    A6KLZ0, D3ZJ29
    Related
    ENSRNOP00000020873.5, ENSRNOT00000020873.5
    Conserved Domains (2) summary
    sd00017
    Location:579 → 600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15926
    Location:437 → 521
    RNF220; E3 ubiquitin-protein ligase RNF220

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    189065036..189075587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283902.1 → XP_063139972.1  zinc finger protein 512B isoform X8

  2. XM_063283900.1 → XP_063139970.1  zinc finger protein 512B isoform X6

  3. XM_063283897.1 → XP_063139967.1  zinc finger protein 512B isoform X1

  4. XM_063283899.1 → XP_063139969.1  zinc finger protein 512B isoform X5

  5. XM_063283898.1 → XP_063139968.1  zinc finger protein 512B isoform X4

  6. XM_039105152.2 → XP_038961080.1  zinc finger protein 512B isoform X2

    UniProtKB/TrEMBL
    D3ZJ29
    Conserved Domains (2) summary
    PHA03247
    Location:265 → 624
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:739 → 760
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_063283901.1 → XP_063139971.1  zinc finger protein 512B isoform X7

  8. XM_039105153.2 → XP_038961081.1  zinc finger protein 512B isoform X3

    UniProtKB/TrEMBL
    A0A8I6AJD9, D3ZJ29
    Related
    ENSRNOP00000095303.1
    Conserved Domains (2) summary
    PHA03247
    Location:265 → 624
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:729 → 750
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_063283904.1 → XP_063139974.1  zinc finger protein 512B isoform X10

  10. XM_063283903.1 → XP_063139973.1  zinc finger protein 512B isoform X9

  11. XM_063283905.1 → XP_063139975.1  zinc finger protein 512B isoform X11

Nucleotide Protein Strain
Heading Accession and Version

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