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Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311726, updated on 3-Apr-2024

Summary

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Official Symbol
Pcmtd2provided by RGD
Official Full Name
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2provided by RGD
Primary source
RGD:1305684
See related
Ensembl:ENSRNOG00000017404 AllianceGenome:RGD:1305684
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305684
Summary
Predicted to enable protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Predicted to be involved in protein methylation. Predicted to be active in cytoplasm. Orthologous to human PCMTD2 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 508.9), Brain (RPKM 265.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q43
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (189337758..189360525)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168960312..168979504)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (177351505..177371470)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene myelin transcription factor 1 Neighboring gene uncharacterized LOC134486518 Neighboring gene uncharacterized LOC120101836 Neighboring gene zinc finger protein 431-like Neighboring gene RNA polymerase III subunit K Neighboring gene ubiquitin-conjugating enzyme E2N, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein-L-isoaspartate O-methyltransferase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107810.1 → NP_001101280.2  protein-L-isoaspartate O-methyltransferase domain-containing protein 2

    See identical proteins and their annotated locations for NP_001101280.2

    Status: PROVISIONAL

    Source sequence(s)
    CH474066
    UniProtKB/TrEMBL
    A6KLV7
    Conserved Domains (1) summary
    pfam01135
    Location:11 → 219
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    189337758..189360525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105160.2 → XP_038961088.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    D3ZY20
    Related
    ENSRNOP00000023989.7
    Conserved Domains (1) summary
    pfam01135
    Location:11 → 193
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

  2. XM_063283907.1 → XP_063139977.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6KLV7

  3. XM_063283909.1 → XP_063139979.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X3

  4. XM_063283910.1 → XP_063139980.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X4

  5. XM_063283906.1 → XP_063139976.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6KLV7

RNA

  1. XR_010064642.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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